Registration Dossier
Registration Dossier
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EC number: 200-370-5 | CAS number: 58-22-0
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
GLP study according to EU Method A.6.(Flask method).
Analytical development Physical Chemistry, Schering AG, Berlin, Study report A01872 (APC 166/200), dated 2002-04-04.
Result: S(20) = 2.41 ± 0.4 mg/L
Key value for chemical safety assessment
- Water solubility:
- 2.41 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of testosterone was determined using the flask method at 20°C to be:
S20 = 2.41 ± 0.4 mg/L
Testosterone can be considered as insoluble in water in accordance with the descriptive term of Ph-Eur. (EP 4th ed.) and USP 25. The pH value of the saturated water solutions was determined to be 6.2.
(According to X-ray powder diffraction the insoluble residues from the suspension in water consist of a mixture of the monohydrates I and II. The dehydration of both leads to polymorph I, which was the starting material.)
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