L-arabinose

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
Due to the low vapour pressure of the test item, which was measured to be 1.89E-8 Pa at 20°C, L-Arabinose is unlikely to be available as a vapor to a large extent. However, the substance is a needle-shaped crystalline solid and has a median particle size (D50) of 51 µm. Deposition patterns of dusts will depend on the particle size, shape and electrostatic properties. Particles with aerodynamic diameters below 100 µm have the potential to be inhaled. Absorption via the inhalation route might occur as dust due to median particle sizes of 51 µm. However, based on adequate data from an Intake Assessment, a history of safe use of L-Arabinose in humans can be concluded. There is no evidence of any adverse effect of this ubiquitous pentose, which is part of the human food chain. In the light of this habitual exposure to L-Arabinose, the safety of L-Arabinose is evident and additional animal trials to study inhalation toxicity is unjustified. In addition and in accordance with Annex XI section 1.2, relevant independent sources of information are available, leading to the conclusion that the substance has not a particular dangerous property. Therefore, further testing on vertebrate animals for that property shall be omitted where adequate and reliable data for the absence of a particular dangerous property is available.
For further information please refer to attached Intake Assessment.