L-arabinose

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2018-04-18 to 2018-05-08

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

method according to Siwoloboff

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Batch No. of test material: AD16081001
- Expiration date of the batch: 2019-08-09

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature
- Stability under test conditions: Stable under ambient conditions

Key result

Atm. press.:

101.02 kPa

Decomposition:

yes

Decomp. temp.:

174.7 °C

Reference Test

The boiling point of water was determined to be 100.0 °C (373.2 K). Measured values were determined to be in the required range (literature value ± 0.5 °C).

Preliminary Test

Preliminary test was performed before the main test. At the end of the measurement bumping was recorded by the device.

Table 1. Preliminary test results

Start temperature, °C	Heating rate, °C/min	Atmospheric pressure, kPa (at the measuring)	Boiling point, °C (at standard atmospheric pressure)
154.6	5	101.02	177.7

Main test

For the main study the metal block was heated to 165 °C. The capillaries containing the test item were placed into the apparatus and the temperature was raised at 1 °C/min heating rate until the boiling temperature was reached. Three tests were carried out. The boiling temperature was determined and the boiling point of the test item was determined to be 174.7 ± 0.80 °C (95 % confidence interval) i.e. 447.8 K. At the end of the measurements bumping was observed.

Before the test (at 165 °C) the test item was a transparent liquid. At the end of the measurements the color of the samples became yellow in the capillary.

Table 2. Main test results

Atmospheric pressure, kPa (at the measuring)	Boiling point, °C (at standard atmospheric pressure)
101.02	174.9
101.01	174.8
101.02	174.3
Mean:	174.7
RSD (CV %):	0.2
Conf.int. (95 %)	0.80

Conclusions:

No boiling point of the test item was determined as the test item decomposes before boiling at 174.7 °C.

Executive summary:

A study was conducted according to OECD test guideline 103, Regulation (EC) No 440/2008 method A.2 and EPA OPPTS 830.8220 to determine the boiling point of the test item using the principle according to Siwoloboff. A small amount of the test item was filled in a capillary tube and was heated in the electronically temperature controlled sample block. In a preliminary test a boiling point of 177.7 °C was observed. This value was introduced as expected boiling temperature for the main test. The sample was heated from 165 °C at rate 1 °C/minute. The sample was observed visually for any possible changes in appearance, consistency and colour. The phase transition from liquid to vapour was deduced by the continuous formation of steam bubbles leaving the inserted boiling capillary. This determination was done in triplicate. The atmospheric pressure was recorded. No boiling point of the test item was determined as the test item decomposes before boiling at 174.7 °C at 101.02 kPa.

Description of key information

No boiling point of the test item was determined as the test item decomposes before boiling at 174.7 °C.

Additional information

A study was conducted according to OECD test guideline 103, Regulation (EC) No 440/2008 method A.2 and EPA OPPTS 830.8220 to determine the boiling point of the test item using the principle according to Siwoloboff. A small amount of the test item was filled in a capillary tube and was heated in the electronically temperature controlled sample block. In a preliminary test a boiling point of 177.7 °C was observed. This value was introduced as expected boiling temperature for the main test. The sample was heated from 165 °C at rate 1 °C/minute. The sample was observed visually for any possible changes in appearance, consistency and colour. The phase transition from liquid to vapour was deduced by the continuous formation of steam bubbles leaving the inserted boiling capillary. This determination was done in triplicate. The atmospheric pressure was recorded.No boiling point of the test item was determined as the test item decomposes before boiling at 174.7 °C at 101.02 kPa.