D,L-DIETHYL TARTRATE

Surface tension

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

June 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: DIN EN 14370 Bestimmung der Oberflächenspannung; November 2004

Deviations:

not specified

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

signed on September 24, 2013

Type of method:

ring method

Key result

Surface tension:

69.3 mN/m

Temp.:

20 °C

Conc.:

1 g/L

Surface Tension of Water: 72.6 mN/m at 19.9 °C

Calibration Factor: The calibration factor was calculated to be 1.003 (72.8 mN/m / 72.6 mN/m).

Results: The surface tension of an aqueous solution of the test item (1 g/L) was determined to be: 69.3 mN/m at 20 °C.

 

Table : Measured Surface Tension of the Test Item (1 g/L)

Replicate No.	Time expired* [min]	Temperature [°C]	Measured [mN/m]	Surface Tension corrected^1[mN/m]	Surface Tension corrected^2[mN/m]
1	0	19.8	69.9	NA
2	15	19.8	69.1
3	30	19.8	69.1
4	45	19.7	69.2
5	60	19.8	69.1
6	75	19.8	69.2
Mean value (n=6)			69.3	69.5	69.3
SD (n=6)			0.3	NA

*Time expired since the test item solution was transferred into the test vessel.

1 corrected for the calibration factor (water) factor: 1.003

2 corrected by Harkins-Jordan-regression (y = 0.7232 * x 1.0756)

rounded values were used for the correction

Conclusions:

The surface tension of an aqueous solution of DIETHYLE TARTRATE (1 g/L) was determined to be: 69.3 mN/m at 20 °C.
Based on the criteria as outlined in the EC Guideline (a substance is considered as surface active if surface tension < 60mN/m in the conditions of the method) and the results of this study, DIETHYL TARTRATE has to be considered as a non-surface active substance.

Executive summary:

The surface tension of DIETHYL TARTRATE was measured under GLP according to OECD 115/EU A5 guidelines,using the ring tensiometer method. Six readings were recorded, and the mean value was retained and corrected with calibration factor from water.

The surface tension of an aqueous solution of the test item (1 g/L) was determined to be 69.3 mN/m at 20 °C.  

Reference 2

Endpoint:

surface tension

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The hypothesis is based on structural similarity (L-form for the test substance instead of racemate product for the target).

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Refer to the Test material section of the source and target records.

3. ANALOGUE APPROACH JUSTIFICATION
Based on structural similarity the target component is expected to have comparable surface-active potential, with regard to the guideline threshold. Therefore the limit value will be considered as qualitative key data for the dossier substance.

4. DATA MATRIX
Source: L-Diethyl Tartrate
Target: Racemate of Diethyl tartrate


Further information is included in IUCLID Section 13.

Reason / purpose for cross-reference:

read-across source

Key result

Surface tension:

69.3 mN/m

Temp.:

20 °C

Conc.:

1 g/L

Conclusions:

The surface tension of an aqueous solution of the test item (1 g/L) was determined to be 69.3 mN/m at 20 °C. (from analogue)
Based on the criteria as outlined in the EC Guideline (a substance is considered as surface active if surface tension < 60mN/m in the conditions of the method) and the results of this study, DIETHYL TARTRATE has to be considered as a non-surface active substance.

Executive summary:

An analogue of Racemate of Diethyl Tartrate, L-Diethyl tartrate, was tested to determine its surface tension under GLP according to OECD 115/EU A5 guidelines,using the ring tensiometer method.

Six readings were recorded, and the mean value was retained and corrected with calibration factor from water.

The surface tension of an aqueous solution of the test item (1 g/L) was determined to be 69.3 mN/m at 20 °C. 

Description of key information

(from analogue)

The surface tension of an aqueous solution of the test item (1 g/L) was determined to be 69.3 mN/m at 20 °C.

Based on the criteria as outlined in the EC Guideline, it has to be considered as a non-surface active substance.

Key value for chemical safety assessment

Surface tension:

69.3

in mN/m at 20°C and concentration in mg/L:

1 000

Additional information

An analogue of Racemate Diethyl Tartrate, L-Diethyl tartrate, was tested to determine its surface tension according to OECD 115/EU A15 guidelines and under GLP. It is considered as a key study. Read-across is considered justified based on chemical similarity. The result is retained as key data.