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Diss Factsheets
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EC number: 214-093-2 | CAS number: 1079-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study available in EPA (TSCA8e submission file). The study was not performed under GLP. The data are well documented and the data acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Primary skin irritation was determined according to the proposed FDA revision of the test for primary skin irritants published in the Federal Register 37, no. 244, Dec. 19, 1972.
The proposed test differs from the procedure described in the Hazardous Substances Labelling Act, Part 191.11, Chapter, Title 21 in that irritation is determined after a 4-hour exposure period rather than after the proviously required 24-hour exposure period. In the proposed test, readings are made 4, 24, and 48 hours after treatment. Animals are to be retained for observation 96 hours after initial application. Any delayed necrosis will be reported, but the data will not be used in determination of irritation indices. A corrosive substance is defined as a material that causes tissue destruction within 48 hours after application on any of the six intact sites with or without similar destruction on the abraded areas. - GLP compliance:
- no
Test material
- Reference substance name:
- Chlorodiphenylphosphine
- EC Number:
- 214-093-2
- EC Name:
- Chlorodiphenylphosphine
- Cas Number:
- 1079-66-9
- Molecular formula:
- C12H10ClP
- IUPAC Name:
- diphenylphosphinous chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 96 hours
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: corrosive at 4h
- Remarks on result:
- other: observation at 4h, 24h and 48h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: corrosive at 4h
- Remarks on result:
- other: observation at 4h, 24h and 48h
- Irritant / corrosive response data:
- All test rabbits exhibited extensive eschar with severe edema.
Any other information on results incl. tables
Skin irritation index
N° |
Skin |
Erythema – Eschar observation |
Edema observation |
Sum Total |
Score |
||||
4h |
24h |
48 |
4h |
24h |
48 |
||||
1 |
Intact |
4 |
4 |
4 |
4 |
4 |
4 |
48 |
8 |
Abraded |
4 |
4 |
4 |
4 |
4 |
4 |
|||
2 |
Intact |
4 |
4 |
4 |
4 |
4 |
4 |
48 |
8 |
Abraded |
4 |
4 |
4 |
4 |
4 |
4 |
|||
3 |
Intact |
4 |
4 |
4 |
4 |
4 |
4 |
48 |
8 |
Abraded |
4 |
4 |
4 |
4 |
4 |
4 |
|||
4 |
Intact |
4 |
4 |
4 |
4 |
4 |
4 |
48 |
8 |
Abraded |
4 |
4 |
4 |
4 |
4 |
4 |
|||
5 |
Intact |
4 |
4 |
4 |
4 |
4 |
4 |
48 |
8 |
Abraded |
4 |
4 |
4 |
4 |
4 |
4 |
|||
6 |
Intact |
4 |
4 |
4 |
4 |
4 |
4 |
48 |
8 |
Abraded |
4 |
4 |
4 |
4 |
4 |
4 |
|||
Primary irritant Score |
8 |
Score = Sum of individual valus for each rabbit divided by 6
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Based on the findings of the in vivo study with rabbits, the test substance is considered to be corrosive to the skin
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