Registration Dossier
Registration Dossier
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EC number: 602-791-3 | CAS number: 122584-18-3
Auto flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative self-ignition temperature (solids)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-01-12 - 2017-04-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.16 (Relative Self-Ignition Temperature for Solids)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Batch n°: I15EB1917
- Analytical purity: 98.9%
- Expiration date: 2017-09-07
- Storage condition: at room temperature - Key result
- Remarks on result:
- no self-ignition observed up to the melting point
- Conclusions:
- Based on the results of the EC A.16 test performed, the test item is considered not a self-heating substance.
- Endpoint:
- auto-ignition temperature, other
- Remarks:
- Minimum ignition temperature dust cloud (BAM oven)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. No information on purity of the substance.
- Qualifier:
- according to guideline
- Guideline:
- other: VDI Guideline 2263 Part 1: Ignition Temperature BAM-oven
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: ESCIS Expert Commission for Safety in the Swiss Chemical Industry, Booklet 1 ''Sicherheitstests fur Chemikalien''.
- Deviations:
- not specified
- GLP compliance:
- not specified
- Conclusions:
- The Minimum Ignition Temperature determined in the BAM oven for T002078 is 450 deg C.
- Endpoint:
- relative self-ignition temperature (solids)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. No information on purity of the substance.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.16 (Relative Self-Ignition Temperature for Solids)
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- other: VDI Guideline 2263 Part 1: Autoignition-Testing as per Grewer
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: ESCIS Expert Commission for Safety in the Swiss Chemical Industry, Booklet 1 ''Sicherheitstests fur Chemikalien''.
- Deviations:
- not specified
- Principles of method if other than guideline:
- Modifications to the EU A.16 Method: A heating rate of 1.0-1.2 deg C/min or 0.6 deg C/min is used instead of 0.5 deg C/min due to an alternative Swiss Chemical Industry method and technical restriction of the apparatus used. Cylindric wire baskets with 0.2 mm openings are used.
- GLP compliance:
- not specified
- Remarks on result:
- no self ignition observed under the test conditions
- Conclusions:
- In conclusion, the tested substance T002078 is not auto-flammable up to the temperature applied in the test run. The substance has no relative self-ignition temperature.
Referenceopen allclose all
A negative result was obtained. No spontaneous ignition occurred and no significant exothermic effect of the test item was observed. It demonstrated that the test item is “not a self-heating substance”. According to the UN guideline, no further testing is required.
After the experiment, the test item had turned into a brown residue and was collected in a container that was placed below the cube. It indicated that the test item had been molten, decomposed and/or reacted during the experiment.
The Minium Ignition Temperature determined in the BAM oven is 450 deg C.
-heating rate: 1.2 deg C/min
-the sample is heated from room temperature (about 20 deg C) to +/-160 deg C (nearby the melting point)
-the sample shows no self-heating to 400 deg C in the test run
Description of key information
The auto-flammability potential of T002078 was determined in a K1 GLP study (Brekelmans, 2017) carried out according to EC A.16. In the EC A.16 test no self-heating was observed up to the melting point of the test item. No relative self-ignition temperature could be determined.
Key value for chemical safety assessment
Additional information
There are two supporting studies available, for which the reliability was not assignable (K4) performed by the Process Safety Center of Janssen Pharmaceutica:
In a study using a BAM oven, the Minimum Ignition Temperature for the test item was determined to be 450°C. Furthermore, the tested substance T002078 showed no relative self-ignition using a Grewer oven.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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