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EC number: 606-948-7
CAS number: 2217-02-9
A pre-natal developmental toxicity test was performed with isobornyl
acetate according to OECD Guideline 414. 20 female Wistar rats were
exposed by gavage to 0 (control) and 1000 mg/kg bw/day test item between
Days 7 and 16 of gestation, in a limit test. On Day 21 of gestation, the
animals were killed and both dams and fetus were examined. The
investigations showed that the repeated oral exposure to the test item
during the sensitive period of organogenesis, do not cause an impairment
of the general health of dams, not disturbing the intrauterine
development of fetus. The morphological examination of fetuses revealed
no evidence for teratogenic effects of the substance. Therefore, the
NOEL of isobornyl acetate for maternal and fetal developmental toxicity
was determined to be 1000 mg/kg bw/day in rats.
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