(1R,2R,4S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol

Endpoint summary

Description of key information

Short-term toxicity to fish. Key study: Read-across approach. The LC50 of the test item in Fathead Minnows (Pimephales promelas) at 96 h exposure period was determined to be between 59-67.8 mg/L.

Short-term toxicity to invertebrates. Key study: Read-across approach. Test method EU method C2, OECD 202. GLP study. Based on the read-across approach, the 48h-EC50 of the test item was determined to be 11.67 mg/L in Daphnia magna in a static closed system.

Short-term toxicity to algae. Key study. Read-across approach. Test method EU Method C3, OECD 201. GLP study. Based on the read-across approach, the 72h-EC50 of the test item was determined to be 9.19 mg/L in algae (based on measured concentration and growth rate) in a closed static system. The 72h-NOEC was 2.63 mg/L.

Toxicity to microorganisms. Key study. Test method according to OECD 301F, GLP study. The NOEC (28d) for microorganism toxicity of the test item was determined to be 100 mg/L (based on biodegradation).

Additional information

Short-term toxicity to fish. Key study: Read-across approach. Two short-term toxicity tests on fish were performed as described in the handbook "Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas)". Based on the read across approach from the experimental data obtained with the analogue substance L-Borneol, the 96h-EC50 in Fathead Minnows (Pimephales promelas) of the test item was determined to be between 33.5-47.8 mg/L and the 96h-LC50 was determined to be between 59 -67.8 mg/L

Short-term toxicity to invertebrates. Key study: Read-across approach. An acute immobilisation test on Daphnia magna was performed on fenchyl acetate in accordance with EU Method C2 and OECD 202. Based on preliminary range-finding test, 20 daphnids (5 per replicate) were exposed to nominal concentrations of 6.25, 12.5, 25, 50 and 100 % v/v saturated solution (corresponding measured geometric means 2.15; 4.80; 10.04; 21.01 and 37.26 mg/L) over an exposure period of 48 hours in a closed static system. The 48h-EC50 was determined to be 14.85 mg/L. Based on these results, the read-across approach was applied and the 48h-EC50 of the test item in Daphnia magna (based on measured concentration and mobility) was determined to be 11.67 mg/L.

Short-term toxicity to algae. Key study: Read-across approach. The effect of fenchyl acetate was assessed on algal growth using the unicellular green alga Pseudokirchneriella subcapitata, over an exposure period of 72 hours in a closed system, according to EU Method C3 and OECD Guideline 201. Based on preliminary range-finding studies, algae were exposed to nominal concentration of 0 (control, 6 replicates), 6.25, 12.5, 25, 50 and 100 % v/v saturated solution (corresponding measured geometric mean 0, 1.73, 3.37, 6.72, 13.79 and 27.96 mg/L). The 72h-EC50 was determined to be 11.69 mg/L in algae (based on measured concentration and growth rate) in a closed static system. The 72h-NOEC was 3.37 mg/L. Based on these results, the read-across was applied and the 72h-EC50 of the test item was determined to be 9.19 mg/L and the 72h-NOEC was 2.63 mg/L.

Toxicity to microorganisms. Key study: A ready biodegradability manometric respirometry test was perfomed on the test item according to OECD Guideline 301F. Under the test conditions, the 28 day-NOEC for microorganism toxicity of the test item was determined to be 100 mg/L since the substance degraded well (74.5% of biodegradation at 28 days) and did not inhibit the biodegradation in the toxicity test (55.3% of biodegradation after 14 days) up to 100 mg/L.