Registration Dossier
Registration Dossier
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EC number: 257-581-0 | CAS number: 51988-14-8
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates
Read across to the Benzoic acid: OECD 202, Daphnia magna, static, EC50(48h): 7.04 (6.25–7.85) mmol/L, i.e. 860 mg/L.
Read across to DMTD: OECD 202, GLP compliance, Daphnia magna, static, EC50(48h): 5.95 mg/L
Toxicity to aquatic algae and cyanobacteria
Read across to DMTD: OECD 201, GLP compliance, Desmodesmus subspicatus (previous name: Scenedesmus subspicatus), static, EC50 (72h, growth rate): > 160 mg/L, NOEC(72h) 20mg/L, EC10(72h, growth rate): 32.86 mg/L
Read across to Benzoic acid: OECD 201, cyanobacteria (blue-green algae) Anabaena inaequalis, A. cylindrica, and A. variabilis, green algae Chlorella pyrenoidosa and Scenedesmus quadricauda, static, EC50 (12-14d): > 10 mg/L
Read across to Benzoate: Scenedesmus quadricauda, LOEC (96h, growth rate): 1630 mg/L
Additional information
The substance 5-mercapto-1,3,4-thiadiazole-2-thiol-benzoate is known to hydrolyse in aqueous solutions.Thus, a hydrolysis test was performed and hydrolysis products were identified in an OECD 111 Guideline study. 1,3,4-Dimercapto-thiadiazol (DMTD, CAS 1072-71-5) and benzoic acid (CAS 65-85-0) were identified as degradation products, where the parent compound's half life was 1.19 h. Therefore data on aquatic toxicity of the hydrolysis products were used in a weight-of-evidence approach.
The acute toxicity values for DMTD in an OECD 202 study with Daphnia magna of EC50(48h) 5.95 mg/L and in an OECD 201 study with Desmodesmus subspicatus of ErC50(72h) > 160 mg/L were below the acute toxicity values in daphnia for benzoic acid of EC50(48h) 860 mg/L and in algae for benzoate of 1630 mg/L, respectively. The lower values of DMTD have been used for hazard evaluation leading to the conclusion "not classified for aquatic toxicity".
Conclusion
Based on the results of the hydrolysis products the registered substance does not need to be classified as toxic to aquatic environment, neither acute nor chronic, according to Regulation (EC) No 1272/2008.
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