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EC number: 255-002-6
CAS number: 40615-36-9
Table 1: Induction of
Luciferase Activity – Overall Induction
= significant induction according to Student’s t-test, p<0.05
In a dermal sensitisation study
conducted according to OECD 442D with 4,4’-Dimethoxytrityl
chloride (purity 100%) in DMSO, the sensitisation potential of
the test item was assessed on the basis of the activation of
keratinocytes using the in vitro KeratinoSens™. Cells were incubated
with the test item for 48 h at 37 °C and later checked for
Sensitisation was scored by
measuring maximum luciferase activity induction (Imax), cell
viability and EC1.5. For both experiment I and II, Imax was greater
than a 1.5 fold increase, cell viability was greater than 70% and
the value for EC1.5 was less than 1000 µM.
Therefore, in this study, the test
chloride is considered to be a skin sensitiser under UN GHS
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