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EC number: 255-002-6
CAS number: 40615-36-9
Two study reports (rated as Klimisch
1) on aquatic organisms are available covering two trophic levels: a
primary producer (freshwater algae, represented by the model species Pseudokirchneriella
subcapitata) and a primary consumer (aquatic invertebrates,
represented by the model species Daphnia magna).
D. magna was exposed for 48
hours to 4,4'-Dimethoxytrityl chloride in a static short-term GLP
toxicity study (OECD 202) at a limit concentration of 4.3 mg/L
(measured, limit of water solubility, loading 100 mg/L nominal). No
effect on D. magna was observed. The test concentration was
determined analytically by HPLC-UV. Therefore, 4,4'-Dimethoxytrityl
chloride is not toxic to D. magna up to the limit of water
The freshwater algae P. subcapitata
was exposed to 4,4'-Dimethoxytrityl chloride for 72 hours in a GLP
toxicity study (OECD 201). In this study a 72 h ErC50(endpoint: growth
rate) of 1.629 mg/L (95 % C.L. 1.079 – 2.417 mg/L) and a 72 h NOErC
(endpoint: growth rate) of 0.537 mg/L were determined. The test
concentrations were determined analytically by HPLC-UV.
Taking into account that
4,4'-Dimethoxytrityl chloride is considered to be not readily
biodegradable based on ThCO2. (Flach 2018) and the lowest effect value
was determined to be > 1 mg/L (ErC50 = 1.629 mg/L), 4,4'-Dimethoxytrityl
chloride has to be classified as "Aquatic Chronic 2" (H411) following
the provisions laid down in the CLP Regulation (Regulation (EC) No
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