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EC number: 225-896-2 | CAS number: 5137-55-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical was performed in rats.
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- NTRL,1992
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- RTECS
- Year:
- 2 017
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance data base ), 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of Methyltricaprylyl Ammonium Chloride (5137-55-3) on rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Methyltrioctylammonium chloride
- EC Number:
- 225-896-2
- EC Name:
- Methyltrioctylammonium chloride
- Cas Number:
- 5137-55-3
- Molecular formula:
- C25H54ClN
- IUPAC Name:
- methyltrioctylammonium chloride
- Details on test material:
- - Name of test material (IUPAC name): methyl(trioctyl)azanium chloride
- Common name: Trioctylmethylammonium
- Molecular formula: C25H54ClN
- Molecular weight: 404.162 g/mol
- Smiles notation: [N+](CCCCCCCC)(CCCCCCCC)(CCCCCCCC)C.[ClH-]
- InChl: 1S/C25H54N.ClH/c1-5-8-11-14-17-20-23-26(4,24-21-18-15-12-9-6-2)25-22-19-16-13-10-7-3;/h5-25H2,1-4H3;1H/q+1;/p-1
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):methyl(trioctyl)azanium chloride
- Molecular formula :C25H54ClN
- Molecular weight :404.162 g/mol
- Substance type:organic
- Physical state:Pale yellow viscous liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- peanut oil
- Details on oral exposure:
- Details on exposure
VEHICLE
- Justification for choice of vehicle: test substance was soluble in Peanut oil. - Doses:
- 223 mg/kg bw
- No. of animals per sex per dose:
- 223 mg/kg bw: 6 male rats
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 223 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 136 - 366
- Remarks on result:
- other: 50% mortality was observed at dose 223 mg/kg bw
- Mortality:
- 50% mortality was observed at dose 223 mg/kg bw
- Clinical signs:
- other: Dominant Clinical signs at lethal dosages like respiratory depression, gastrointestinal hypermotility,diarrhea, labored breathing and discharge from eye were observed.
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 223 mg/kg (95% confidence limits:136-366 mg/kg),when 6 male rats were treated with Methyltricaprylyl Ammonium Chloride (5137-55-3) orally.
- Executive summary:
Acute oral toxicity study was done in 6 male rats using test material Methyltricaprylyl Ammonium Chloride (5137-55-3).Peanut oil was used as vehicle.50% Mortality was observed at dose 223 mg/kg bw.Dominant Clinical signs at lethal dosages like respiratory depression, gastrointestinal hypermotility,diarrhea, labored breathing and discharge from eye were observed.Hence,LD50 value was considered to be223 mg/kg bw(95% confidence limits:136-366 mg/kg),when rats were treated with Methyltricaprylyl Ammonium Chloride (5137-55-3)orally.
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