Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 946-512-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Read-across data from Guinea Pig Maximization Test on C16 TMAC
Read-across data from Buehler Test on C16 TMAC
See read-across justification attached in section 13
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No indication of sensitising properties. SCCS conclude in their opinion (SCCS/1246/09): "..it must be recognised that quaternary ammonium compounds are not known to be sensitising, but merely corrosive. There are some rare clinical reports, but considering the many years of use of these compounds, they are considered to be of minor importance. Therefore there is no reason to consider cetrimonium chloride, steartrimonium chloride or behentrimonium chloride as skin sensitisers."
Migrated from Short description of key information:
SCCS evaluated this OECD 406 study to be negative. SCCS also found a Buehler test on cetrimonium chloride negative.
Justification for selection of skin sensitisation endpoint:
Data on cetrimonium chloride (C16 TMAC) are used for prediction of the sensitisation of reaction mass of C12 trimethylammonium bromide and C14 trimethylammonium bromide.
A OECD 406 (GPMT) study on cetrimonium chloride is relevant for read-across.
Justification for classification or non-classification
The substance is not considered to be a skin sensitizer according to read-across from data on cetrimonium chloride that was found negative in GPMT and Buehler testing.
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