1-(3,5-Dihydroxyphenyl)-1-oxo-2-(N-1-(4-methoxyphenyl)isopropylamino)ethane Hydrobromide

Appearance / physical state / colour

Administrative data

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Feb 27, 2017 - Mar 6, 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Feb 27, 2017 - Mar 6, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

GLP compliance:

yes (incl. QA statement)

Type of method:

capillary method

Specific details on test material used for the study:

TH 1165 Keton I Br
Batch number 600CC
solid/white
99.9% w/w purity
MW=396.3 g/mol
no density given
expiry date: 31 Mar 2020
storage conditions: ambient (5-30 deg C), dark, dry

Key result

Decomposition:

yes

Decomp. temp.:

200 °C

In the preliminary capillary test accoring to OECD guideline 102 and EC method A.1. no melting point could be observed as the test substance started to decompose at a temperature of 200 °C. The test item began to change its color from white over yellow and light red to black at 200°C . This behavior of the test item leads to the conclusion that TH 1165 Keton I BR decomposes and has no melting point.

Conclusions:

The test item has no melting point down to 30degC using a preliminary test according to OECD 102 (1995) and EC method A.1 as TH 1165 Keton I BR started to decompose at a temperature of about 200degC (473 K). This behavior of the test item leads to the conclusion that TH 1165 Keton I BR decomposes and has no melting point

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The Appearance/physical state and colour were sourced from the review of melting point test (as determined according to EC Methods A.1 and OECD Test Guidelines 102 (1995)).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-(3,5-dihydroxyphenyl)-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide

EC Number:

928-779-0

Cas Number:

1178555-23-1

Molecular formula:

C18-H21-N-O4 x HBr

IUPAC Name:

1-(3,5-dihydroxyphenyl)-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide

Test material form:

solid: particulate/powder

Results and discussion

Physical state at 20°C and 1013 hPa:

solid

Remarks:

Based on the test item decomposing before melting at a tempreature of 200°C and as described in the study referred to.

Form / colour / odour

Key result

Form:

solid: particulate/powder

Colour:

white

Substance type:

organic

Applicant's summary and conclusion

Conclusions:

The physical state and appearance of the test item is a white solid/particulate at 20°C and 1013 hPa, based on the test item having no melting point and decomposing before melting at a tempereture of about 200°C, as described in the study referred to. The result is considered to be reliable.