1-(3,5-Dihydroxyphenyl)-1-oxo-2-(N-1-(4-methoxyphenyl)isopropylamino)ethane Hydrobromide

Auto flammability

Administrative data

Endpoint:

relative self-ignition temperature (solids)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-04-12 - 2017-04-20

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria, Rev. 6 (2015) and UN-Model Regulations, Rev. 19 (2015)

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: VDI 2263 Sheet 1 Grewer Oven (1990)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-(3,5-dihydroxyphenyl)-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide

EC Number:

928-779-0

Cas Number:

1178555-23-1

Molecular formula:

C18-H21-N-O4 x HBr

IUPAC Name:

1-(3,5-dihydroxyphenyl)-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide

Test material form:

solid: particulate/powder

Results and discussion

Relative self-ignition temperature (solids)

Key result

Remarks on result:

no self ignition observed under the test conditions

Remarks:

The pure test item indicated a small self-heating at atmospheric pressure at a temperature of approx. 180 °C and turned into an endothermic process at 200 °C. No self-ignition was observed.

Any other information on results incl. tables

In the investigation of self-ignition in the Grewer Oven for the pure test item a small exothermic effect starts at approx. 180 °C and turns into an endothermic process at 200 °C, which can be assigned to the melting of the test item. After this the temperature of the test item was permanent over the reference temperature (5 – 10 K) until the maximum temperature of 425 °C (415 °C reference). This effect is explained to the changed physical condition of the test item. After the measurement the test item in the basket was changed to bloated black flakes.

For the test item in mixture with Kieselguhr an exothermic effect was observed at approximately 180 °C and 230 °C, which led to a maximum temperature of 630 °C.Table 1summarizes the results of the Grewer Oven experiment

Table1: Results of the screening test for self-ignition in the Gewer-Oven

Experiment	Onset self- ignition / °C	Maximum temperature / °C	Remarks
Pure test item	---	425	Figure4,Figure5
Test item in mixture with Kieselguhr (1:1)	180 / 230	630

Applicant's summary and conclusion

Conclusions:

The pure test item indicated a small self-heating at atmospheric pressure at a temperature of approx. 180 °C and turned into an endothermic process at 200 °C. No self-ignition was observed.