Registration Dossier
Registration Dossier
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EC number: 252-279-5 | CAS number: 34907-26-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From collection of data covering multiple studies, not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- See attached for read-across supporting information.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The genotoxicity of 202-746-4 has been investigated
- GLP compliance:
- not specified
- Remarks:
- Data from collection/ handbook, no informaiton on completion date or compliace is available.
- Type of assay:
- other: Numerous studies performed using the AMES Test.
Test material
- Reference substance name:
- 2,6-dichloro-4-nitroaniline
- EC Number:
- 202-746-4
- EC Name:
- 2,6-dichloro-4-nitroaniline
- Cas Number:
- 99-30-9
- Molecular formula:
- C6H4Cl2N2O2
- IUPAC Name:
- 2,6-dichloro-4-nitroaniline
- Test material form:
- solid
- Details on test material:
- Molecule for read-across studies
Constituent 1
- Specific details on test material used for the study:
- Read-across molecule, test material specifics are not available.
Method
Species / strain
- Species / strain / cell type:
- not specified
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- Results taken from read-across to multiple studies.
Results and discussion
Test results
- Key result
- Species / strain:
- not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- ambiguous
- Remarks:
- Occasional positive results in ames test.
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- not specified
- Remarks:
- Results taken from review of multiple studies
- Untreated negative controls validity:
- not specified
- Remarks:
- Results taken from review of multiple studies
- Positive controls validity:
- not specified
- Remarks:
- Results taken from review of multiple studies
- Additional information on results:
- Occasional positive results in ames test. Unlikely to be genotoxic.
- Remarks on result:
- other: Occasional positive results in ames test. Unlikely to be genotoxic.
Applicant's summary and conclusion
- Conclusions:
- Numerous tests, gave occasional positive results in ames test. Unlikely to be genotoxic.
- Executive summary:
Numerous tests, gave occasional positive results in ames test. Unlikely to be genotoxic.
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