2-hydroxypropyl [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] carbonate

Endpoint summary

Description of key information

Acute toxicity studies evaluating the toxicity of the substance to aquatic organisms are available for four different trophic levels:

Trophic level	Species	Parameter	Endpoint	Value (mg/L)
Fish	Oncorhynchus mykiss	mortality	96-h LC50	17.1
Invertebrates	Daphnia magna	mobility	48-h EC50	8.8
Algae	Pseudokirchneriella subcapitata	growth rate	72-h ErC50	21.0
Microorganisms	activated sludge of a predominantly domestic sewage	respiration	3-h EC50	>62.5

 

Additional information

Acute toxicity studies evaluating the toxicity of the substance to aquatic organisms are available for four different trophic levels. All studies were performed according to international guidelines and GLP. Aquatic invertebrates (Daphnia magna) turned out to be the most sensitive species with an 48-hour EC50 of 8.8 mg/L followed by freshwater fish (Oncorhynchus mykiss; 96-hour LC50: 17.1 mg/L) and aquatic algae (Pseudokirchneriella subcapitata; 72-hour ErC50 of 21 mg/L) based on inhibition of growth.

The toxicity to the microbial community was studied in a 3-hour static Limit test. The activated sludge was exposed to the test item concentration of 62.5 mg/L which corresponds to the highest test concentration that could be prepared due to the limited solubility of the test material in water. The 3-hour EC50 value for inhibition of respiration was determined to be >62.5 mg/L. No inhibition of the degradation process in sewage treatment plants is expected.