Registration Dossier
Registration Dossier
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EC number: 610-465-7 | CAS number: 49621-56-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Deviations:
- no
- Remarks:
- The study was performed in compliance with the following regulations or guidelines: • OECD Guideline for the Testing of Chemicals No. 437 (updated 26 July 2013) “Bovine Corneal Opacity and Permeability Assay” • Method B.47 of Commission Regulation (EC) No
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-(3,4-Dimethoxyphenyl)propanenitrile
- EC Number:
- 610-465-7
- Cas Number:
- 49621-56-9
- Molecular formula:
- C11H13NO2
- IUPAC Name:
- 3-(3,4-Dimethoxyphenyl)propanenitrile
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
In vitro
Results
- Irritation parameter:
- cornea opacity score
- Value:
- ca. 9.2
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No prediction of eye irritation can be made.
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