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EC number: 610-465-7 | CAS number: 49621-56-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- Deviation to the study plan concerning Expiry date of 1% aqueous methylcellulose According to the study plan: 20 August 2007 Deviation: 23 August 2007 Reason for deviation: Mistyping in the Study Plan Presume effect on the Study: None
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 3-(3,4-Dimethoxyphenyl)propanenitrile
- EC Number:
- 610-465-7
- Cas Number:
- 49621-56-9
- Molecular formula:
- C11H13NO2
- IUPAC Name:
- 3-(3,4-Dimethoxyphenyl)propanenitrile
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of this study, the acute oral LD50 value of the test item was between 740-2000 mg/kg body weight in female CRL: (WI) BR rats.
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