Registration Dossier
Registration Dossier
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EC number: 203-937-5 | CAS number: 112-12-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- The study is from a secondary literature
Data source
Reference
- Reference Type:
- other: Secondary literature
- Title:
- Methyl Nonyl Ketone: Reregistration Eligibility Decision (RED)
- Author:
- US EPA
- Year:
- 1 995
- Bibliographic source:
- United States Environmental Protection Agency, July 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Undecan-2-one
- EC Number:
- 203-937-5
- EC Name:
- Undecan-2-one
- Cas Number:
- 112-12-9
- Molecular formula:
- C11H22O
- IUPAC Name:
- undecan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): Methyl nonyl ketone
- Common name: 2-Undecanone
- Molecular formula: C11H22O
- Molecular weight: 170.294 g/mol
- Smiles notation: C(CCCCCC)CCC(C)=O
- InChl: 1S/C11H22O/c1-3-4-5-6-7-8-9-10-11(2)12/h3-10H2,1-2H3
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- not specified
- Concentrations:
- 5430 mg/m³
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 5 430 mg/m³ air
- Based on:
- test mat.
- Mortality:
- No mortality was observed
- Clinical signs:
- other:
- Body weight:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation toxicity dose (LC50) was considered to be >5430 mg/m³, when rats were exposed to Methyl nonyl ketone via inhalation route.
- Executive summary:
Acute inhalation toxicity study was performed in rats using test chemical Methyl nonyl ketone (CAS no.: 112 -12 -9, E.C. no.: 203 -937 -5). Rats were treated at a dose concentration of 5430 mg/m³. Animals were further observed for clinical signs of toxicity and mortality. No mortality was observed at dose 5430 mg/m³. Hence, the LC50 value was considered to be >5430 mg/m³, when rats were treated with test chemical Methyl nonyl ketone. The test chemical can be considered as "Not classified" according to the CLP.
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