Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary sources
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Determination of hydrolysis of test chemical at different pH range.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Duration:
30 d
Temp.:
25 °C
Remarks:
Study was performed at pH 5, 7 and 9, respectively.
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Key result
pH:
5
Temp.:
25 °C
DT50:
> 30 d
Remarks on result:
other: Chemical is stable i.e not hydrolysed at pH 5, 7 and 9, respectively. At the end of the 30 day study, the mass balance of test chemical was 84.7-98.8%.
Key result
pH:
7
Temp.:
25 °C
DT50:
> 30 d
Remarks on result:
other: Chemical is stable i.e not hydrolysed at pH 5, 7 and 9, respectively. At the end of the 30 day study, the mass balance of test chemical was 94-103.1%.
Key result
pH:
9
Temp.:
25 °C
DT50:
> 30 d
Remarks on result:
other: Chemical is stable i.e not hydrolysed at pH 5, 7 and 9, respectively. At the end of the 30 day study, the mass balance of test chemical was 90.7-101.5%.
Details on results:
Test chemical was reported to be hydrolytically stable at pH 5, 7 and 9, respectively and at a temperature of 25°C. Material balance ranges from 87.5 to 100.8% of the applied radioactivity,
Validity criteria fulfilled:
not specified
Conclusions:
The half-life value of test chemical was determined to be >30 days and thus, chemical was considered as hydrolytically stable at pH 5, 7 and 9, respectively and at a temperature of 25°C.
Executive summary:

The half-life of the test chemical was determined at different pH range. Test vessel was incubated in the dark at 25°C for 30 days. The half-life value of test chemical was determined to be >30 days at pH 5, 7 and 9, respectively and at a temperature of 25°C. Material balance ranges from 87.5 to 100.8% of the applied radioactivity. Based on this, it is concluded that the chemical was considered as stable in water.

Description of key information

The half-life of the test chemical was determined at different pH range. Test vessel was incubated in the dark at 25°C for 30 days. The half-life value of test chemical was determined to be >30 days at pH 5, 7 and 9, respectively and at a temperature of 25°C. Material balance ranges from 87.5 to 100.8% of the applied radioactivity. Based on this, it is concluded that the chemical was considered as stable in water.

Key value for chemical safety assessment

Half-life for hydrolysis:
30 d
at the temperature of:
25 °C

Additional information

The half-life of the test chemical was determined at different pH range. Test vessel was incubated in the dark at 25°C for 30 days. The half-life value of test chemical was determined to be >30 days at pH 5, 7 and 9, respectively and at a temperature of 25°C. Material balance ranges from 87.5 to 100.8% of the applied radioactivity. Based on this, it is concluded that the chemical was considered as stable in water.

 

In addition to this, as per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable.