Registration Dossier
Registration Dossier
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EC number: 240-387-5 | CAS number: 16298-03-6
Surface tension
Administrative data
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 February 2013 - 26 April 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Version / remarks:
- (1995)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- OECD harmonised ring method
Test material
- Reference substance name:
- Methyl 3-aminopyrazinecarboxylate
- EC Number:
- 240-387-5
- EC Name:
- Methyl 3-aminopyrazinecarboxylate
- Cas Number:
- 16298-03-6
- Molecular formula:
- C6H7N3O2
- IUPAC Name:
- methyl 3-aminopyrazine-2-carboxylate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Amiloride Compound 6
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen
Constituent 1
Results and discussion
Surface tension
- Surface tension:
- 73.3 mN/m
- Temp.:
- 20 °C
- Conc.:
- 1 g/L
Any other information on results incl. tables
Surface tension measurements
Measurement
|
Time passed [minutes] |
Surface tension [mN/m] |
||
Individual |
Mean |
mean corrected (1) |
||
1 |
16 |
72.6 |
||
2 |
17 |
72.4 |
72.6 |
73.3 |
3 |
18 |
72.8 |
||
4 |
19 |
72.6 |
||
5 |
20 |
72.7 |
||
(1) multiplied by Φb and corrected according to Harkins-Jordan
Applicant's summary and conclusion
- Conclusions:
- The surface tension of an aqueous solution of the substance at 1 g/L was determined to be 73.3 mN/m at 20°C using the OECD Harmonized ring method (GLP-compliant study in accordance with EC A.5 and OECD 115). Because this is not < 60 mN/m, Amiloride Compound 6 is not surface active according to the EC A.5 guideline.
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