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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-981-5 | CAS number: 112-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity to Daphnia pulex of six classes of chemical compounds potentially hazardous to Great Lakes aquatic biota
- Author:
- Smith, S. B.; Savino, J. F.; Blouin, M. A.
- Year:
- 1 988
- Bibliographic source:
- J. Great Lakes Res. 14 (4): 394-404
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- American Society of Testing and Materials 1980. E729-80
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- US EPA 1975. Report No. 660/3-75-009
- Deviations:
- not specified
- Principles of method if other than guideline:
- the test has been conducted in accordance to the standards of American Society of Testing and Materials (1980) No. E729-80 and US EPA (1975) Report No. 660/3-75-009.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-chlorododecane
- EC Number:
- 203-981-5
- EC Name:
- 1-chlorododecane
- Cas Number:
- 112-52-7
- Molecular formula:
- C12H25Cl
- IUPAC Name:
- 1-chlorododecane
Constituent 1
- Specific details on test material used for the study:
- CAS No. 112-52-7
Mol Wt. 205
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- Solvent control is mentioned (acetone), but not specified if used for substance
Reconstituted hard water.
Test organisms
- Test organisms (species):
- Daphnia pulex
- Details on test organisms:
- Daphnia pulex cultured in reconstituted hard water at 20°C fed with a mix of green algae species.
Less than 24 h old
no feeding during test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- total hardness 160-180 mg/L as CaCO3
- Dissolved oxygen:
- dissolved oxygen concentration 8-9 mg/L
- Nominal and measured concentrations:
- five concentrations, range not further specified
- Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers in water bath at 20°C
- No. of organisms per vessel: min. 10 Neonates/ test vessel
- Control and solvent control
EFFECT PARAMETERS MEASURED: immobilisation after 48 h
VEHICLE CONTROL PERFORMED: not specified
- Reference substance (positive control):
- yes
- Remarks:
- p,p' DDT
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.013 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- +/- SE 0.0019 mg/L
- Results with reference substance (positive control):
- DDT showed an EC50 of 0.0011 mg/L after 48 h.
- Reported statistics and error estimates:
- EC50 value were calculated by probit analysis and analysis of variance (ANOVA).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The EC50 of the test substance has been determined to be 0.013 mg/L and has been considered as very highly toxic for invertebrates in comparison to other alkyl halides.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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