Registration Dossier
Registration Dossier
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EC number: 413-110-2 | CAS number: 135861-56-2
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
As the substance is not considered to be toxic or harmful after oral and dermal exposure, acute (systemic) DNELs do not need to be derived. As the substance is not considered to be irritating to skin and eyes, acute (local) DNELs do not need to be derived.
Only signs of unspecific toxicity (effects on body weight gain) were observed at a dose higher than the limit dose in a 90-d study in rats. The test substance does not pose any specific risk following repeated oral exposure.
The results of the OECD 421 study (NOEL = 1000 mg/kg bw nominal) did not indicate adverse effects on reproductive organs or tissues and no concern exists in relation with reproductive toxicity. In addition, an OECD 415 (1-gen study) conducted with a structural analogue also did not indicate any adverse effects.
As the substance is not considered to be hazardous with respect to long-term effects, long term (systemic) DNELs do not need to be derived. As local effects were not observed in the repeated dose toxicity study, long term (local) DNELs do not need to be derived.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The substance is not readily available to consumers, as there is very little potential for the substance to be released from the polymers once it has been consumed in the polymer manufacturing process. Therefore, DNELs for the general population do not need to be derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
