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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Analytical Expert Group ETAD
Principles of method if other than guideline:
About 5 mg of the test sample were suspended in 30 mL octanol (Aldrich, spectrophotometric grade) in a sample flask (standard flask for the Büchi Rack R-24, volume 30 mL) and were shaken for two hours at 30°C (+/- 2°C) on a "Büchi Syncore Polyvap" with 400 rpm. Then shaking was continued at ambient temperature (22 - 23°C) for 70 hours, followed by filtration 3 times through a 0.2 µm membrane filter.
The resulting clear solution was measured by UV-vis spectrometry and the absorption was determined at 520 nm. The determination was repeated three times.

Calibration for determination of concentration of the samples applying the Lambert-Beer rule: calibration curve of 1-((4-methoxy-2-nitrophenyl)azo)-2-naphthol in chloroform.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
n-octanol
Solubility:
<= 72 mg/L
Temp.:
22 °C
Remarks on result:
other: mean of 3 measurements
Test substance stable:
yes

Any other information on results incl. tables

The solubility of the sample 1 -((4 -methoxy-2 -nitrophenyl)azo)-2 -naphthol in n-octanol at ambient temperature, determined under the conditions as mentioned above, is 72 mg/L (mean, n = 3,sigma= 0.4).

Table 1: Individual results

   Absorption (d = 10 cm)  mg/L
 a1 1.0757  71.6
 a2 1.0841  72.2
 a3 1.0865

72.3

Applicant's summary and conclusion