Registration Dossier
Registration Dossier
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EC number: 243-654-4 | CAS number: 20262-76-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study in rats
- Author:
- Commission of the European Communities
- Year:
- 1 988
- Bibliographic source:
- Scientific Committee on Cosmetology (seventh series)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the skin irritation potential of the test chemical in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrogen [4-[4-(diethylamino)-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium, sodium salt
- EC Number:
- 204-934-1
- EC Name:
- Hydrogen [4-[4-(diethylamino)-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium, sodium salt
- Cas Number:
- 129-17-9
- Molecular formula:
- C27H32N2O6S2.Na
- IUPAC Name:
- hydrogen [4-[4-(diethylamino)-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium, sodium salt
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Patent Blue V- Molecular formula : C27H31N2O6S2.NaC27H32N2O6S2.Na - Molecular weight : 566.672 g/mole- Substance type: Organic- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: saline
- Controls:
- not specified
- Amount / concentration applied:
- 0. 5 ml of saturated solution in saline
- Duration of treatment / exposure:
- no data available
- Observation period:
- no data available
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: not mentioned
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The test chemical was observed to be not irritating to rabbit skin.
- Executive summary:
A skin irritation study was conducted in rabbits to observe the irritation potential of the test chemical.
0. 5 ml of a saturated solution of the test chemical in saline was applied to rabbit skin (site not specified) and effects were observed (duration not specified).
The test chemical was observed to be not irritating to rabbit skin.
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