Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 243-654-4 | CAS number: 20262-76-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
- The substance is not metabolised by rat or human microsomal enzymes;
- Patent blue V has low absorption and limited systemic availability;
- It is mainly exctreted in faeces.
Key value for chemical safety assessment
Additional information
An in vitro study was performed in 2011 (Guerbet/Eurofins, Study of Patent Blue V metabolisation on human and rat microsome, 88 pages, February 16, 2011) in order to measure the metabolism of E131 Patent blue V in hepatic microsomes from rats and humans: the substance is not metabolised at concentrations of 1 to 100 μM.
Several in vivo studies demonstrated that the substance is not metabolised and completely excreted in 72 hours with no accumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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