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Diss Factsheets
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EC number: 202-845-2 | CAS number: 100-37-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
2-Diethylaminoethanol was not carcinogenic to rats when given by feed for 2 years in a limited 1960’s study (tested up to ca. 50 – 400 mg/kg/d). While this data is limited, the lack of a carcinogenic effect of 2-diethylaminoethanol is supported by the negative data for genotoxicity.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 50 mg/kg bw/day
Justification for classification or non-classification
2-Diethylaminoethanol (DEAE) was not found to be carcinogenic to rats in a 2 -year repeated dose feeding study conducted in the sixties, i.e., prior to the implementation of the current guidelines. Nevertheless, the data obtained from this study are acceptable for assessment and indicate lack of a carcinogenic potential for DEAE, which is further supported by negative data for genotoxicity.
Thus, there is no need for classification according to the EU Directive 67/548/EEC and to the CLP Regulation EC/1272/2008.
Additional information
The carcinogenic potential of DEAE was examined within a 2 year repeated dose feeding study (Pennsalt 1967; Val. 2). Each test group comprised 35 rats/sex whereas the control group comprised 60 rats/sex. The testes dose levels were 0, 200, 500 and 1000 ppm, corresponding to ca. 11, 25 and 50 mg/kg bw/day. It has to be noticed that the initial high dose level of 1000 ppm (i.e. 50 mg/kg bw/day) was increased step by step over the course of the study until reaching 10,000 ppm (i.e., ca. 400 mg/kg bw/day). The data referring to the systemic toxicity are entered and discussed in IUCLID chapter 7.5.1. Referring to carcinogenicity, tumours were found in both sexes in all control and treated groups. The majority (more than 90%) of the tumours appeared within the final 6 months of the study or were discovered at the time of necropsy. As evidenced by the gross necropsy and micropathological results, the onset, type, size and frequency of the tumours were similar amongst the DEAE-treated and control groups, and the development of the neoplastic structures within the test groups could not be related to ingestion of the test preparation in the diet. Thus, no carcinogenic potential could be evidenced for DEAE in the present 2 -year repeated dose feeding study.
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