Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-845-2 | CAS number: 100-37-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 165 mg/L
Additional information
The short-term toxicity of 2-diethylaminoethanol to aquatic invertebrates was investigated in a study according to EU Method C.2 (BASF AG, 1988). Based on nominal test concentrations the 48-h EC50 was determined to be 83.6 mg/L; the test solutions were not neutralized in this study.
The nominal concentrations were 0 (control), 7.81, 15.6, 31.2, 62.5, 125, 250, and 500 mg/l; they were not analytically verified, but are assumed to be stable due to the the low n-octanol/water partition coefficient (log Kow = 0.21), the high water solubility (WS = 1.0E+06 mg/L at 23 °C), the moderate vapour pressure (VP = 2 hPa, at 22.4 °C) and the low Henry´s law constant (HLC, uncharged: 3.17E-04 Pa*m³/mol) of the chemical. Furthermore, the substance was found to be stable during a test on short-term toxicity to fish conducted according to APHA (1980) standard methods for the examination of water and waste water which are similar to OECD 203 testing guideline (Geiger et al., 1986).
In addition, a further test on short-term toxicity to aquatic invertebrates according to OECD 202 (Atofina, 1993) showed an acceptable recovery of the test item in the test solutions. Based on nominal concentrations, the 48-h EC50 was 165 mg/L.
With regard to the EC50, the effect values show a significantly higher toxicity using non-neutralized test solutions; therefore, the observed toxicity is partly due to the pH induced by the substance. For risk assessment the effect data for the neutralized test medium should be used, since the quantities of 2-diethylaminoethanol that would be found in natural waters are not likely to affect the pH to a relevant extend. It is likely that the EC50 value from the test without neutralization overestimates the potential toxicity of the target item.
Based on the data for neutralized test solutions (48-h EC50 = 165 mg/L), the substance is assessed to be with high probability not harmful to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
