Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-343-1 | CAS number: 10124-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation supporting studies:
1.Sodium Hexametaphosphate (concentration not specifed) had the maximum primary irritation index (PII) score of 8.0 in the standard Draize dermal irritation assay using six rabbits. All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.
2. Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant) in the standard Draize dermal irritation assay using six rabbits.
Eye irritation supporting studies:
Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review, data insufficient for assesment.
- Principles of method if other than guideline:
- Standard Draize dermal irritation assay.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Remarks on result:
- other: All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.
- Executive summary:
Sodium Hexametaphosphate (concentration not specifed) had the maximum primary irritation index (PII) score of 8.0 in the standard Draize dermal irritation assay using six rabbits. All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.
Information poorly documented, insuficient for classification.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review, data insufficient for assesment.
- Principles of method if other than guideline:
- Standard Draize dermal irritation assay.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Amount / concentration applied:
- 0.5g dossolved in appropiate solvent (concentration not speciffied)
- Duration of treatment / exposure:
- Patches were applied under 1 x1-inch gauze pads to the intact and abraded skin of six albino rabbits. The patches were attached to the skin with adhesive tape and the trunk of each rabbit was wrapped in a rubberized cloth sheath for 24 hours.
- Number of animals:
- 6
- Remarks on result:
- other: Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant).
- Irritant / corrosive response data:
- Sodium Hexametaphosphate had a PII of 1.62 (mild irritant).
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant).
- Executive summary:
Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant) in the standard Draize dermal irritation assay using six rabbits.
Information poorly documented, insuficient for classification.
Referenceopen allclose all
All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- Evaluated using the Illustrated Guide for Grading Eye Irritation Caused by Hazardous Substances.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Animals weights from 1.6 to 2.1 kg
- Vehicle:
- water
- Amount / concentration applied:
- Ten milligrams of concentrated Sodium Hexametaphosphate or 0.1 ml of a 0.2% solution in water was instilled into the conjunctival sac of the eye.
- Remarks on result:
- other: Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.
- Executive summary:
The test was performed with 6 New Zealand White rabbits. Ten milligram of concentrated Sodium Hexametaphosphate or 0.1 ml of a 0.2% solution in water was instilled into the conjunctival sac of the eye.
The untreated eye of each rabbit served as its control. The eyes were then observed at 24, 48, and 72 hours.
Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and non remissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.
Reference
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.