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Diss Factsheets
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EC number: 233-343-1 | CAS number: 10124-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study does not meet some study design and analytical criteria
- Principles of method if other than guideline:
- Sodium hexametaphosphate (HEX), the solvent of calcium alginate wool used in swabbing inanimate surfaces was studied relative to its effect on various bacterial populations, both pure cultures and wild.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 24 h
- Details on results:
- It was found that bacteria in wild populations were greatly inhibited, and that a percentage reduction of count was directly related to concentration of HEX.
Most gram-positive bacteria were prevented from growing on a medium containing 0.1 % HEX. This, or a higher concentration, occurred in the final medium when the method
recommended in Standard Methods for the Examination of Dairy Products was followed. Growth of Sarcina lutea occurred on media with higher concentrations than that of
inhibition (0.05 %), if MgSO4 7H20 was incorporated in the medium. Gram-negative bacteria were capable of growing in higher concentrations, even up to 10 % HEX.
A large percentage of the cells of some strains (represented by Pseudomonas fluorescens) were lysed on contact with HEX. Lysis could be prevented by the addition of NaCl or MgSO4-7H20. The evidence presented suggests that HEX, a phosphate-glass water-softening sequestrant, interferes with divalent cation metabolism, notably magnesium ion, and possibly others, producing cell division inhibition and loss of cell-wall integrity. - Validity criteria fulfilled:
- not applicable
- Conclusions:
- It was found that bacteria in wild populations were greatly inhibited, and that a percentage reduction of count was directly related to concentration of HEX.
Most gram-positive bacteria were prevented from growing on a medium containing 0.1 % HEX. This, or a higher concentration, occurred in the final medium when the method
recommended in Standard Methods for the Examination of Dairy Products was followed. Growth of Sarcina lutea occurred on media with higher concentrations than that of
inhibition (0.05 %), if MgSO4 7H20 was incorporated in the medium. Gram-negative bacteria were capable of growing in higher concentrations, even up to 10 % HEX.
A large percentage of the cells of some strains (represented by Pseudomonas fluorescens) were lysed on contact with HEX. Lysis could be prevented by the addition of NaCl
or MgSO4-7H20. The evidence presented suggests that HEX, a phosphate-glass water-softening sequestrant, interferes with divalent cation metabolism, notably magnesium ion, and possibly others, producing cell division inhibition and loss of cell-wall integrity. - Executive summary:
The result of the study is that it was found that bacteria in wild populations were greatly inhibited, and that a percentage reduction of count was directly related to concentration of Sodium hexametaphosphate (HEX).
Most gram-positive bacteria were prevented from growing on a medium containing 0.1 % Sodium hexametaphosphate (HEX). This, or a higher concentration, occurred in the final medium when the method recommended in Standard Methods for the Examination of Dairy Products was followed. Growth of Sarcina lutea occurred on media with higher concentrations than that of inhibition (0.05 %), if MgSO4 7H20 was incorporated in the medium. Gram-negative bacteria were capable of growing in higher concentrations, even up to 10 % Sodium hexametaphosphate (HEX).
A large percentage of the cells of some strains (represented by Pseudomonas fluorescens) were lysed on contact with HEX. Lysis could be prevented by the addition of NaCl or MgSO4 7H20. The evidence presented suggests that HEX, a phosphate-glass water-softening sequestrant, interferes with divalent cation metabolism, notably magnesium ion, and possibly others, producing cell division inhibition and loss of cell-wall integrity.
Reference
Description of key information
Supporting Study:
The result of the study is that it was found that bacteria in wild populations were greatly inhibited, and that a percentage reduction of count was directly related to concentration of Sodium hexametaphosphate.
Most gram-positive bacteria were prevented from growing on a medium containing 0.1 % Sodium hexametaphosphate (HEX). This, or a higher concentration, occurred in the final medium when the method recommended inStandard Methods for the Examination of Dairy Productswas followed. Growth of Sarcina lutea occurred on media with higher concentrations than that of inhibition (0.05 %), if MgSO4 7H20 was incorporated in the medium. Gram-negative bacteria were capable of growing in higher concentrations, even up to 10 % Sodium hexametaphosphate.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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