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EC number: 946-413-8
CAS number: -
In an acute oral toxicity study performed
according to the OECD Guideline 423 and in compliance with GLP, a single
dose of 2000 mg/kg bw of the test substance in DMSO was given by oral
gavage to a group of 6 female Wistar rats. Animals were then observed
for mortality and clinical signs of toxicity for 14 days.
No mortality occurred during the study. An
increase of salivation was noted in the first hours of the test in one
animal (1/6). Then a decrease of spontaneous activity, muscles tones and
righting reflex was noted 24 hours post dose associated with a noisy
breathing. The animal recovered normal activity on day 3. No other signs
of systemic toxicity were noted. The body weight evolution of the
animals remained normal during the study. The macroscopic examination of
the animals at the end of the study did not reveal any treatment related
Rat Oral LD50 >2000 mg/kg bw.
Under the test conditions, the oral LD50 of
the test substance is >2000 mg/kg bw in rats. In accordance with OECD
Guideline 423, the LD50 cut-off of the test substance may be considered
to be >5000 mg/kg bw by oral route in the rat. Therefore it is not
classified according to the Regulation (EC) N° 1272-2008 and according
to the Globally Harmonised System of classification and labelling of
chemicals (GHS). No signal word or hazard statement is required.
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