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EC number: 258-203-7 | CAS number: 52821-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report 1-VINYL-2-PYRROLIDONE
- Author:
- EUROPEAN COMMISSION JOINT RESEARCH CENTRE
- Year:
- 2 003
- Bibliographic source:
- European Union Risk Assessment Report 1-VINYL-2-PYRROLIDONE; EUROPEAN COMMISSION JOINT RESEARCH CENTRE; Final Report, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to contemporary regulatory protocols.
- Principles of method if other than guideline:
- The Buehler test was performed in guinea pigs to determine the sensitization potential of test chemical 1-ethenylpyrrolidin-2-one (CAS No: 88-12-0) according to contemporary regulatory protocols under an occlusive condition.
- GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- 1-ethenylpyrrolidin-2-one
- Cas Number:
- 88-12-0
- Molecular formula:
- C6H9NO
- IUPAC Name:
- 1-ethenylpyrrolidin-2-one
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1-ethenylpyrrolidin-2-one
- Molecular formula: C6H9NO
- Molecular weight: 111.1431 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: C=CN1CCCC1=O
- InChI: 1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Concentration: 100%
Amount: 0.25 ml - Day(s)/duration:
- 6 hours
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Concentration: 100%
Amount: 0.25 ml - Day(s)/duration:
- 6 hours
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 20
- Details on study design:
- RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period:6 hours
- Test groups:20
- Control group:10
- Site: flanks
- Frequency of applications: once per week on three successive weeks
- Duration: 6 hours
- Concentrations: 100% (0.25 ml)
B. CHALLENGE EXPOSURE
- No. of exposures:1
- Day(s) of challenge: Fourteen days after the final induction application,
- Exposure period:6 hours
- Test groups:20
- Control group:10
- Site: opposite flanks
- Concentrations: 100% (0.25 ml)
- Evaluation (hr after challenge): 24 and 48 hours - Challenge controls:
- The control group of 10 guinea pigs remained untreated.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100%(0.25 ml)
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No signs of irritation and no systemic toxicity were observed.
- Remarks on result:
- no indication of skin sensitisation
In vivo (LLNA)
- Cellular proliferation data / Observations:
- Although a concurrent positive control assay was not performed, the laboratory had obtained a positive result in a Buehler test using α-hexylcinnamaldehyde within 6 months of this test, thus validating the sensitivity of the assay protocol.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The test material 1-ethenylpyrrolidin-2-one (CAS No: 88-12-0) was considered to be not sensitizing to the skin of guinea pigs in a Buehler test.
- Executive summary:
The Buehler test was performed in guinea pigs to determine the sensitization potential of test chemical 1-ethenylpyrrolidin-2-one (CAS No: 88-12-0) according to contemporary regulatory protocols under an occlusive condition.
During induction, 20 guinea pigs received undiluted 0.25 ml of 1-ethenylpyrrolidin-2-one on the flanks under an occlusive dressing and held in place for 6 hours. The treatment occurred once per week on three successive weeks. Since 1-ethenylpyrrolidin-2-one was applied without use of a vehicle, the control group of 10 guinea pigs remained untreated.
After 14 days of the final induction application, animals were challenged on opposite flanks to the for 6 hours under occlusive condition and application sites scored 24 and 48 hours after removal of the patches.
No signs of irritation and no systemic toxicity were observed during the induction and challenge phase. Therefore the chemical 1-ethenylpyrrolidin-2-one (CAS No: 88-12-0) was considered to be not sensitizing to the skin of guinea pigs.
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