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EC number: 258-203-7 | CAS number: 52821-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid, pharmacologically acceptable salts thereof and compositions containing the same for treatment of diabetes mellitus complications
- Author:
- Efimov , et al.
- Year:
- 1 986
- Bibliographic source:
- United States Patent Document. #4598081
- Reference Type:
- other: Authoritative database
- Title:
- RTECS Number: CF6559500
- Author:
- RTECS database
- Year:
- 2 017
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) (CAS No. 88909-96-0) in rat by the oral route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 88909-96-0
- Molecular formula:
- C16H13NO4
- Details on test material:
- - Name of test material: Isodibut (1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid)
- Molecular formula: C16H13NO4
- Molecular weight: 283.282 g/mol
- Smiles notation: C1(N(C(c2c3c(cccc13)ccc2)=O)CCCC(=O)O)=O
- InChl: 1S/C16H13NO4/c18-13(19)8-3-9-17-15(20)11-6-1-4-10-5-2-7-12(14(10)11)16(17)21/h1-2,4-7H,3,8-9H2,(H,18,19)
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Isodibut (1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid)
- Molecular formula: C16H13NO4
- Molecular weight: 283.282 g/mol
- Smiles notation: C1(N(C(c2c3c(cccc13)ccc2)=O)CCCC(=O)O)=O
- InChl: 1S/C16H13NO4/c18-13(19)8-3-9-17-15(20)11-6-1-4-10-5-2-7-12(14(10)11)16(17)21/h1-2,4-7H,3,8-9H2,(H,18,19)
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Females (if applicable) nulliparous and non-pregnant: No data available
- Age at study initiation: Mature animals were used for the experiment.
- Weight at study initiation: 180 to 220 g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: No data available
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: No data available
- Lot/batch no. (if required): No data available
- Purity: No data available
MAXIMUM DOSE VOLUME APPLIED: No data available
DOSAGE PREPARATION (if unusual): No data available
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data available - Doses:
- 3000 mg/kg bw
3500 mg/kg bw
4000 mg/kg bw
4500 mg/kg bw
5000 mg/kg bw
5500 mg/kg bw
6000 mg/kg bw - No. of animals per sex per dose:
- A total of 36 rats were used in the experiment.
3000 mg/kg bw : 5 animals
3500 mg/kg bw : 5 animals
4000 mg/kg bw : 4 animals
4500 mg/kg bw : 5 animals
5000 mg/kg bw : 7 animals
5500 mg/kg bw : 5 animals
6000 mg/kg bw : 5 animals - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 5 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs, mortality. - Statistics:
- LD50 determined by the Lichfield and Wilcoxon method, or the Van der Waerden method was used as an index of high toxicity.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 030 - 5 280
- Mortality:
- Only a few animals showed a short-time initial excitation. 6-8 hours later the animals laid down on the side, their condition became comatose, followed by death. That is the animals died slowly, as a rule, during the first 24-26 hours.
3000 mg/kg bw : 0/5
3500 mg/kg bw : 2/5
4000 mg/kg bw : 1/4
4500 mg/kg bw : 3/5
5000 mg/kg bw : 4/7
5500 mg/kg bw : 4/5
6000 mg/kg bw : 5/5 - Clinical signs:
- other: The symptoms of the acute lethal poisoning by 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) was characterized by flaccidity, hypodynamia, and lower respiration rhythm.
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified based on CLP criteria
- Conclusions:
- The acute oral median lethal dose (LD50) of 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) (CAS No. 88909-96-0) in rat was observed to be 4000 (3030 to 5280) mg/kg b.wt.
- Executive summary:
The toxicity of 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) (CAS No. 88909-96-0) was examined by way of experiment performed on rats. Mature animals both male and female, weighting 180 to 220 g (rats) were used for said experiment. 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) was administered perorally. The drug was introduced in the form of a starch suspension through a gastric tube. A total of 36 rats were used in the experiment. Rats were given dosages of 3000 mg/kg bw to 6000 mg/kg bw. The animals were kept under observation for 5 days. The symptoms of the acute lethal poisoning by 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) was characterized by flaccidity, hypodynamia, and lower respiration rhythm. Only a few animals showed a short-time initial excitation. 6-8 hours later the animals laid down on the side, their condition became comatose, followed by death. That is the animals died slowly, as a rule, during the first 24-26 hours. Doses of up to 3000 mg/kg bw caused no deaths but 2 animals died at 3500 mg/kg bw, 1 animal died at 4000 mg/kg bw, 3 animals died at 4500 mg/kg bw, 4 animals died at 5000 mg/kg bw, 4 animals died at 5500 mg/kg bw and 5 animals died at 6000 mg/kg bw. Thus, the acute oral median lethal dose (LD50) of 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) (CAS No. 88909-96-0) in rat was observed to be 4000 (3030 to 5280) mg/kg b.wt. Therefore, according to CLP criteria for acute toxicity rating for the chemicals, it infers that 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid (Isodibut) (CAS No. 88909-96-0) does not exhibit acute toxicity via the oral route.
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