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EC number: 203-951-1 | CAS number: 112-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report does not specify about GLP but equivalent to OECD guideline no 401 and sufficient data is available for the interpretation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C6H13OCH2CH2OH
- IUPAC Name:
- 2-hexyloxyethanol
- Details on test material:
- - Name of test material (as cited in study report): Hexyl CELLOSOLVE (Ethylene glycol monohexyl ether)
- Physical state: Clear, non-viscous liquid
- Lot/batch No.: S074565
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not specified in the report
- Age at study initiation: Not specified in the report
- Weight at study initiation: 200-300 g
- Fasting period before study: Overnight
- Housing: Not specified in the report
- Diet ( ad libitum): Not specified in the report
- Water ( ad libitum): Not specified in the report
- Acclimation period: Not specified in the report
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not specified in the report
- Humidity (%): Not specified in the report
- Air changes (per hr): Not specified in the report
- Photoperiod (hrs dark / hrs light): Not specified in the report
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Sprague-Dawley albino rats, weighing between 200 and 300 g, receive the test material by stomach intubation with a ball-end stainless steel needle. The sample is injected through the needle by means of a syringe and doses are varied by adjusting the volume of the test material or its dilution. The rats are fasted overnight before dosing. Five males and 5 females are included on each level used for the LD50 calculations.
- Doses:
- For male rats: 2.00 ml/kg, 1.41 ml/kg, 1.00 ml/kg and 0.50 ml/kg
For female rats: 4.0 ml/kg, 2.0 ml/kg, 1.0 ml/kg, 0.71 ml/kg, 0.50 ml/kg and 0.25 ml/kg - No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weights and gross pathology - Statistics:
- LD50's and the estimated LD50 slopes are calculated by the moving average method (Thompson, 1947; Weil, 1983) and are based on a 14-day observation period.
Results and discussion
- Preliminary study:
- none
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.67 mL/kg bw
- 95% CL:
- 1.43 - 1.96
- Remarks on result:
- other: 1484 mg/kg
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 0.83 mL/kg bw
- 95% CL:
- 0.71 - 0.97
- Remarks on result:
- other: 738 mg/kg
- Mortality:
- For male rats: 2.00 ml/kg (5/5), 1.41 ml/kg (0/5), 1.00 ml/kg (5/0) and 0.50 ml/kg (0/3)
For female rats: 4.0 ml/kg (3/3), 2.0 ml/kg (3/3), 1.0 ml/kg (5/5), 0.71 ml/kg (0/0), 0.50 ml/kg (0/0) and 0.25 ml/kg (0/0) - Clinical signs:
- other: Signs of toxicity included sluggishness, lacrimation, drooping eyelids, piloerection, labored breathing, red perinasal discharge (in 2) and prostration. Deaths occurred at 3 hours to 3 days. Survivors recovered at one to 3 days.
- Gross pathology:
- At necropsy, there were mottled and red lungs, red or liquid-filled stomachs, urinary bladders with red fluid and one liver nodule.
- Other findings:
- None
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this study acute oral LD50 for male and female rats receiving peroral doses of Hexyl CELLOSOLVE is 1.67 ml/kg (1484 mg/kg) and 0.83 ml/kg (738 mg/kgbw ) respectively.
- Executive summary:
Ethylene glycol monohexyl ether was evaluated for acute oral test in rats. Sprague-Dawley albino rats, weighing between 200 and 300 g, received the Hexyl CELLOSOLVE (Ethylene glycol monohexyl ether) by stomach intubation with a ball-end stainless steel needle. The sample was injected through the needle by means of a syringe and doses are varied by adjusting the volume of the test material or its dilution. The rats were fasted overnight before dosing. Five males and 5 females are included on each level used for the LD50 calculations.
Signs of toxicity included sluggishness, lacrimation, drooping eyelids, piloerection, labored breathing, red perinasal discharge (in 2) and prostration. Deaths occurred at 3 hours to 3 days. Survivors recovered at one to 3 days. All survive animals gained body weights during 14 days of observation period. At necropsy, there were mottled and red lungs, red or liquid-filled stomachs, urinary bladders with red fluid and one liver nodule.
Based on the results of this study acute oral LD50 for male and female rats receiving peroral doses of Hexyl CELLOSOLVE is 1.67 ml/kg (1484 mg/kg) and 0.83 ml/kg (738 mg/kg bw) respectively.
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