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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed document

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs: METHYL NONELYNATE
Author:
D.L.J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology, 14,811, 1976
Reference Type:
secondary source
Title:
Safety evaluation of certain food additives
Author:
World Health Organization
Year:
1999
Bibliographic source:
the Fifty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO FOOD ADDITIVES SERIES: 42,World Health Organization, Geneva, 1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Reefer below principle
Principles of method if other than guideline:
Acute oral toxicity study of methyl non-2-enoate in rat
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl non-2-enoate
EC Number:
203-908-7
EC Name:
Methyl non-2-enoate
Cas Number:
111-79-5
Molecular formula:
C10H18O2
IUPAC Name:
methyl non-2-enoate
Test material form:
liquid
Details on test material:
- Name of test material: methyl (2E)-non-2-enoate
- Molecular formula: C10H18O2
- Molecular weight: 170.25 g/mol
- Smiles notation: C(\C=C\C(OC)=O)CCCCC
- InChl: 1S/C10H18O2/c1-3-4-5-6-7-8-9-10(11)12-2/h8-9H,3-7H2,1-2H3/b9-8+
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): METHYL NONYLENATE
- Molecular formula (if other than submission substance): C10H18O2
- Molecular weight (if other than submission substance): 170.25 g/mole
- Substance type: Organic
- Physical state: Colorless liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
5000 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality observed at 5000 mg/kg bw in treated rat.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 5000 mg/kg bw when rat were treated with Methyl non-2-enoate orally.
Executive summary:

In acute oral toxicity study,rat were treated with Methyl non-2-enoate orally in the concentration of 5000 mg/kg bw. No mortality observed at 5000 mg/kg bw in treated rat. Therefore, LD50 was considered to be > 5000 mg/kg bw when rat were treated with Methyl non-2-enoate orally.