Methyl non-2-enoate

Endpoint summary

Description of key information

Short term toxicity to aquatic invertebrates:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the eight closest read across substances, toxicity on daphnia magna was predicted for 111-79-5 (Methyl non-2-enoate). The EC50 value was estimated to be 102.651405334 mg/l when Methyl non-2-enoatewas exposed to Daphnia magna for 48hrs.

Toxicity to aquatic algae and cyanobacteria:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) was predicted for 111-79-5 (Methyl non-2-enoate). The EC50 value was estimated to be 121.08 mg/l when Methyl non-2-enoatewas exposed to Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) for 48hrs.

Additional information

Summarized results of toxic effect of the chemical Methyl non-2-enoate on the growth and other normal activities of aquatic lifes, by the collection of data from various databases and also predicting the effects of chemical on the basis of structure similarities.

Short term toxicity to aquatic invertebrates:

Toxicity of chemical Methyl non-2-enoate on the growth of aquatic life’s have been studied and concluded the nature and classification category on the basis of data obtain from various sources, RA chemicals and also from predicted QSAR reports which support the classification of the target chemical.

In the first weight of evidence study for 11-79-5 from QSAR toolbox version 3.3, 2017, Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the eight closest read across substances, toxicity on daphnia magna was predicted for 111-79-5 (Methyl non-2-enoate). The EC50 value was estimated to be 102.651405334 mg/l when Methyl non-2-enoatewas exposed to Daphnia magna for 48hrs.

Similarly in the another weight of evidence study for RA chemical n-Butyl lactate (138-22-7) butyl 2-hydroxypropanoate, from gestis, ecotox, and HSDB databases, Evaluation of short term toxicity of n-Butyl lactate on the growth of Daphnia magna for 48 hrs was carried out. Test performed by the standard static method for 2 days. Based on the data obtain from above various sources, there was decrease in mobility of daphnia magna due to n-Butyl lactate, and the EC50 was 320 mg/l. Thus n-Butyl lactate was consider as not toxic and can be consider as not classified as per the CLP classification criteria.

 

Similarly in another weight of evidence study for RA chemical n-Hexyl acetate (142-92-7), 2-methylpentyl acetate 3-methylpentyl acetate 4-methylpentyl acetate hexyl acetate, from GSBL databases was studied. Determination of short term toxicity of n-Hexyl acetate on the growth of daphnia magna. The study was carried out for 24 hrs in the static system. Based on the buoyancy of daphnia magna, because of n-Hexyl acetate the EC0 was 144 mg/l. Based on the data for the chemical n-Hexyl acetate, the chemical was nontoxic and it can be consider as not classified as toxic as per the CLP classification criteria.

 

Thus based on the data available for Methyl non-2-enoate (111-79-5), from various databases gestis, ecotox, HSDB, GSBL, and QSAR toolbox version 3.3, Methyl non-2-enoate was consider to be nontoxic and thus can be consider to be not classified as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria:

Toxicity of chemical Methyl non-2-enoate on the growth of aquatic life’s have been studied and concluded the nature and classification category on the basis of data obtain from various sources, RA chemicals and also from predicted QSAR reports which support the classification of the target chemical.

In the first weight of evidence study for 11-79-5 from QSAR toolbox version 3.3, 2017 was studied. Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) was predicted for 111-79-5 (Methyl non-2-enoate). The EC50 value was estimated to be 121.08 mg/l when Methyl non-2-enoatewas exposed to Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) for 48hrs.

 

Similarly in another weight of evidence study for RA chemical n-Butyl lactate (138-22-7) butyl 2-hydroxypropanoate from ecotox, 2017. Evaluation of short term toxicity of n-Butyl lactate, on the growth of Pseudokirchneriella subcapitata for 72-96 hrs. Test performed by the standard static method. Based on the data obtain from above source for biomass inhibition of green algae due the exposure of n-Butyl lactate the EC50 was 329 mg/l. Thus n-Butyl lactate was consider as not toxic and can be consider as not classified as per the CLP classification criteria.

 

Similarly according to the third weight of evidence study for RA chemical n-Butyl lactate (138-22-7) butyl 2-hydroxypropanoate from ecotox, 2017 chemical was consider as not toxic to aquatic life. Evaluation of short term toxicity of n-Butyl lactate, on the growth of Pseudokirchneriella subcapitata for 72-96 hrs. Test performed by the standard static method. Based on the data obtain from above various source growth rate inhibition of green algae due the exposure of n-Butyl lactate the EC50 was 929 mg/l. Thus n-Butyl lactate was consider as not toxic and can be consider as not classified as per the CLP classification criteria.

 

 

Thus based on the data available for Methyl non-2-enoate (111-79-5), from various databases ecotox, and QSAR toolbox version 3.3, Methyl non-2-enoate was consider to be nontoxic and thus can be consider to be not classified as per the CLP classification criteria.