Registration Dossier
Registration Dossier
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EC number: 201-744-0 | CAS number: 87-41-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature. Unreliable Test Institute (IBT)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 5 rabbits, after application of TS rabbits were wrapped, exposure time 4 hrs, symptoms were recorded, gross autopsy
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Phthalic anhydride
- EC Number:
- 201-607-5
- EC Name:
- Phthalic anhydride
- Cas Number:
- 85-44-9
- Molecular formula:
- C8H4O3
- IUPAC Name:
- 2-benzofuran-1,3-dione
- Details on test material:
- - Name of test material (as cited in study report): Phthalic anhydride
- Purity: no data
- Other: melting point: 130.8 °C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
TEST MATERIAL
- Concentration (if solution): 50% suspension
- Constant volume or concentration used: yes
- Duration of exposure:
- 4 hours
- Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- no death occurred
- Clinical signs:
- No signs of systemic intoxication were observed, local signs observed were mild erythema and oedema on removal of the wrappings. Recovery
occurred at the same day. - Body weight:
- no data
- Gross pathology:
- Gross autopsy revealed no significant findings.
Any other information on results incl. tables
Unreliable test institute (IBT).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
