Registration Dossier
Registration Dossier
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EC number: 224-152-4 | CAS number: 4216-02-8
Endpoint summary
Administrative data
Description of key information
C.I. Pigment Red 194 (PR 194) is insoluble in water (0.96 mg/L) and no functional groups are present in the molecule that could hydrolize. Therefore the pigment is regarded as hydrolytically stable. In addition, due to the very low solubility in water, testing is technically not feasible.
Due to the poor water solubility, the potential for biodegradation was assumed to be very low. Ready bioldegradability was assessed for the Source Substance C.I. Pigment Orange 43 in the Manometric Respirometry Test according to OECD 301F. In this reliable test (reliability category 1) performed compliant to GLP and fulfilling validity criteria of the guideline, after 28 days a biodegradation rate of 6 % was reached while a functional control (sodium benzoate) proved the activity of the system. Therefore, the Target Substance PR 194 is regarded as not readily biodegradable.
Because of the low log Pow-value -0.24 (<< 3), according to column 2 of Annex VIII of regulation (EC) No 1907/2006 no testing of absorption-desorption behaviour of the substance is required. An absorption/desorption screening test according to OECD 121 (HPLC estimation method) could not be expected to yield any reasonable information. In addition, due to the very low solubility in water and in n-octanol, testing is technically not feasable.
Additional information
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