Registration Dossier
Registration Dossier
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EC number: 204-368-5 | CAS number: 120-07-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Animal experimental study, predates implementation of GLP and/or development of study guidelines, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard: Two white Vienna rabbits were treated for 1, 5 and 15 minutes and for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with moistened test substance. After the application time, the skin was washed. Animals were observed for 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-phenyliminodiethanol
- EC Number:
- 204-368-5
- EC Name:
- 2,2'-phenyliminodiethanol
- Cas Number:
- 120-07-0
- Molecular formula:
- C10H15NO2
- IUPAC Name:
- 2-[(2-hydroxyethyl)(phenyl)amino]ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dioxyäthyl-anilin
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: female 2.77 kg, male 2.91 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other:
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 80% aqueous test substance preparation.
- Duration of treatment / exposure:
- 1, 5, 15 min, and 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- Application area: 2.5 x 2.5 cm2
After the application time the skin was washed with 50% Lutrol/water
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No irritation was observed after 24 hours and 8 days on the animals exposed for 1, 5, 15 minutes and 20 hours.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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