Registration Dossier
Registration Dossier
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EC number: 204-368-5 | CAS number: 120-07-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Animal experimental study, predates implementation of GLP and/or development of study guidelines, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard: Six young adult rats per sex were exposed to 0.1 mg/L dust. After an observation period of 7 days animals were necropsied.
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-phenyliminodiethanol
- EC Number:
- 204-368-5
- EC Name:
- 2,2'-phenyliminodiethanol
- Cas Number:
- 120-07-0
- Molecular formula:
- C10H15NO2
- IUPAC Name:
- 2-[(2-hydroxyethyl)(phenyl)amino]ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dioxyäthyl-anilin
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 177 g
Administration / exposure
- Route of administration:
- inhalation: dust
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 200 L/h - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 0.1 mg/L
- No. of animals per sex per dose:
- 12
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.1 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- No mortality observed.
- Clinical signs:
- other: No clinical signs observed.
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
