Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971

Materials and methods

Principles of method if other than guideline:
Female albino rabbits received a single application of the test material to clipped skin which was covered with rubber sheeting for 24 hours. One rabbit was treated at 1 g/kg, 1 rabbit at 2 g/kg and 3 rabbits at 3 g/kg. The application was left in contact with the skin for 24 hours and the animals were then observed for 7 days.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw

Applicant's summary and conclusion