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EC number: 419-060-8 | CAS number: 79026-02-1 AUFHELLER 2001; ELV 1094
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
None - Analytical monitoring:
- yes
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The study was performed with young daphnids of a clone of the species Daphnia magna Straus. The clone was originally supplied by the University of Sheffield/UK in 1992, defined from the supplier as clone 5. Since this date the clone is bred in the laboratories of RCC in reconstituted water of identical quality (regarding pH, main ions and total hardness) and under identical temperature and light conditions as in the tests. At the start of the test the used test organisms were 6-24 hours old and were not first brood progeny.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No data
- Hardness:
- 2.5 mmol/l (= 250.0 mg/l) as CaC03
- Test temperature:
- 21 °C during the test period
- pH:
- 7.8 to 8.0
- Dissolved oxygen:
- The dissolved oxygen concentrations in the test medium and the control were at least 8.1 mg/l.
- Salinity:
- No data
- Nominal and measured concentrations:
- Nominal concentration : 100mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:The beakers were covered with glass plates to reduce the loss of water and to avoid the entry of dust into the solutions.
- Aeration:The test water was aerated until oxygen saturation was reached. During the test period the test water was not aerated.
TEST MEDIUM / WATER PARAMETERS
- Alkalinity:0.8 mmol/l
- Ca/mg ratio:4:1 (based on molarity) - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- A limit test was performed in accordance with the guidelines to demonstrate that the test item has no toxic effect on the test organisms up to and including the highest test item concentration which could be dissolved or very finely dispersed in test water.
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours), and the 48-hour ECO of FAT 60253/A to Daphnia magna were determined to be at least 0.010 mg/l (loading rate of 100 mg/l).
- Executive summary:
The acute toxicity of the test item FAT 60253/A to Daphnia magna was determined in a 48-hour static test according to the Commission Directive 92/69/EEC, Part C.2 (1992), and the OECD Guideline for Testing of Chemicals, No. 202, Part I (1984). A limit test was performed in accordance with the Commission Directive 92/69/EEC to demonstrate that the test item has no toxic effect on the test organisms up to and including the highest test item concentration which can be dissolved or very finely dispersed in test water. Due to the very low water solubility of the test item, a supersaturated dispersion of the test item with a loading rate of 100 mg/l was continuously stirred at room temperature in the dark over 7 days. Then, the dispersion was filtered. Only the undiluted filtrate with the maximum concentration of dissolved and very finely dispersed test item was used as the test medium. Additionally, a control was tested in parallel. The analytically determined test item concentration in the test medium were 0.0093 and 0.011 mg/l at the start and the end of the test period, respectively. Under the test conditions, the test item was stable during the test period of 48 hours. All biological results are related to the mean measured test item concentration of 0.010 mg/l, calculated as the average of all measurements. In the control and in the undiluted filtrate, no immobilized or dead test organisms or other signs of intoxication were determined during the test period of 48 hours. The 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours), and the 48-hour EC0 of FAT 60'253/A to Daphnia magna were determined to be at least 0.010 mg/l (loading rate of 100 mg/l). The 48-hour NOEC and the 48 -hour EC0 might even be higher but concentrations of the test item above the maximum concentration which could be dissolved or very finely dispersed in the test water were not tested, according to the guidelines. The 48-hour EC50 and the 48-hour EC100 were clearly higher than the solubility limit of the test item in the test water. These values could not be quantified, since the test item had no toxic effect on the daphnids at the highest test item concentration which could be dissolved or very finely dispersed in the test water.
Reference
None
Description of key information
The 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours), and the 48-hour ECO of FAT 60253/A to Daphnia magna were determined to be at least 0.010 mg/l (loading rate of 100 mg/l).
Key value for chemical safety assessment
Additional information
The acute toxicity of the test item FAT 60253/A to Daphnia magna was determined in a 48-hour static test according to the Commission Directive 92/69/EEC, Part C.2 (1992), and the OECD Guideline for Testing of Chemicals, No. 202, Part I (1984). A limit test was performed in accordance with the Commission Directive 92/69/EEC to demonstrate that the test item has no toxic effect on the test organisms up to and including the highest test item concentration which can be dissolved or very finely dispersed in test water. Due to the very low water solubility of the test item, a supersaturated dispersion of the test item with a loading rate of 100 mg/l was continuously stirred at room temperature in the dark over 7 days. Then, the dispersion was filtered. Only the undiluted filtrate with the maximum concentration of dissolved and very finely dispersed test item was used as the test medium. Additionally, a control was tested in parallel. The analytically determined test item concentration in the test medium were 0.0093 and 0.011 mg/l at the start and the end of the test period, respectively. Under the test conditions, the test item was stable during the test period of 48 hours. All biological results are related to the mean measured test item concentration of 0.010 mg/l, calculated as the average of all measurements. In the control and in the undiluted filtrate, no immobilized or dead test organisms or other signs of intoxication were determined during the test period of 48 hours. The 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours), and the 48-hour EC0 of FAT 60'253/A to Daphnia magna were determined to be at least 0.010 mg/l (loading rate of 100 mg/l). The 48-hour NOEC and the 48-hour EC0 might even be higher but concentrations of the test item above the maximum concentration which could be dissolved or very finely dispersed in the test water were not tested, according to the guidelines. The 48-hour EC50 and the 48-hour EC100 were clearly higher than the solubility limit of the test item in the test water. These values could not be quantified, since the test item had no toxic effect on the daphnids at the highest test item concentration which could be dissolved or very finely dispersed in the test water.
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