Registration Dossier
Registration Dossier
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EC number: 613-855-5 | CAS number: 65928-65-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- not applicable
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 2.15
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: 95 % confidence limits: (1.93 - 2.37)
- Conclusions:
- The partition coefficient (logPow) was determined to be 2.15 at 25 °C and pH7.
- Executive summary:
The n-octanol/water partition coefficient (log Pow) was determined according to EU Testing Guideline A.8 (HPLC method based on OECD guideline No. 117) to be 2.15 (95 % confidence limits 1.93 -2.37) at 25 °C and pH 7 which indicates no lipophilicity. The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.
Reference
The log Pow value of the test compound was calculated from its log k' and the calibration line to be (at 25 °C):
compound |
retention times [min] | log k' | log Pow | |||
| 1. | 2. | 3. | mean | |||
| Test item | 2.09 | 2.10 | 2.10 | 2.10 | -0.04 | 2.15 |
The evaluations were made with the program Pow 1.3 (PDR Informatik, Schering AG).
Description of key information
The partition coefficient (log Pow) was determined to be 2.15 at 25 °C and pH7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.15
- at the temperature of:
- 25 °C
Additional information
There is no classification expected resulting out of the studies concerning the partition coefficient.
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