3,7-dimethylnon-6-en-1-yn-3-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1996

Report date:

1996

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

no

Principles of method if other than guideline:

-

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethylnon-6-en-1-yn-3-ol

EC Number:

246-061-9

EC Name:

3,7-dimethylnon-6-en-1-yn-3-ol

Cas Number:

24173-47-5

Molecular formula:

C11H18O

IUPAC Name:

3,7-dimethylnon-6-en-1-yn-3-ol

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

semiocclusive

Preparation of test site:

clipped

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5 mL of undiluted test article

Duration of treatment / exposure:

4 h

Observation period:

14 days

Number of animals:

3

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

24/48/72 h

Score:

2

Max. score:

2

Reversibility:

fully reversible within: 14 d

Results 2

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

24/48/72 h

Score:

1.7

Max. score:

2

Reversibility:

fully reversible within: 14 d

Results 3

Irritation parameter:

erythema score

Basis:

animal #3

Time point:

24/48/72 h

Score:

1.3

Max. score:

2

Reversibility:

fully reversible within: 14 d

Results 4

Irritation parameter:

edema score

Basis:

animal #1

Time point:

24/48/72 h

Score:

1.7

Max. score:

2

Reversibility:

fully reversible within: 14 d

Results 5

Irritation parameter:

edema score

Basis:

animal #2

Time point:

24/48/72 h

Score:

2.3

Max. score:

3

Reversibility:

fully reversible within: 14 d

Results 6

Irritation parameter:

edema score

Basis:

animal #3

Time point:

24/48/72 h

Score:

0.7

Max. score:

1

Reversibility:

fully reversible within: 14 d

Other effects:

-

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:

Category 3 (mild irritant) based on GHS criteria

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

It is considered that the test article, Ethyldehydrolinalool, is a slight irritant
to rabbit skin under the conditions of this study.

Executive summary:

The purpose of this study was to assess the degree of irritation produced by the test article, Ethyldehydrolinalool, when applied to the intact skin of the albino rabbit. The procedures used meet the requirements of OECD Guideline No. 404, adopted 17th

July 1992. A 0.5 ml aliquot of the test article was applied over a previously clipped area of the dorsal skin of each of 3 albino rabbits. The test article was held in contact with the skin, under a semiocclusive patch assembly, for a 4 hour period. The patch was then removed and the treated site gently cleansed with water. Skin reaction, i.e. erythema and eschar as well as oedema

formation, was assessed 1, 24, 48 and 72 hours after patch removal. Additional assessments of

skin reaction were made 7 and 14 days after dosing. Treatment with the test article produced a skin reaction characterised by very slight to well defined erythema and barely perceptible to moderate oedema in all 3 animals. This response

persisted 7 days after dosing but was no longer apparent in any animal at the end of the 15 day observation period.

The primary irritation index was calculated to be 2.8.