Registration Dossier
Registration Dossier
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EC number: 208-792-1 | CAS number: 541-73-1
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute hepatic and renal toxicity of dichlorobenzene isomers in Fischer 344 rats
- Author:
- Valentovic MA, Ball JG, Anestis D, & Madan E
- Year:
- 1 993
- Bibliographic source:
- Journal of applied Toxicology, Vol.13(1), 1-7
Materials and methods
- Principles of method if other than guideline:
- Male Fischer 344 rats were injected with 1,3-dichlorobenzene. Hepatic and renal toxicity was quantitated 24 hour after injection of 1,3-dichlorobenzene.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- 1,3-dichlorobenzene
- EC Number:
- 208-792-1
- EC Name:
- 1,3-dichlorobenzene
- Cas Number:
- 541-73-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,3-dichlorobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- 24-48 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2, 3 or 4mmol/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4
- Control animals:
- other: pair fed control (PFC) animals were injected (i.p) with corn oil
Results and discussion
- Details on results:
- Liver morphology was relatively normal in rats treated with 1,3-dichlorobenzene. 1,3-dichlorobenzene showed only minimal effects on the kidney.
Any other information on results incl. tables
Liver morphology was relatively normal in rats treated with 1, 3-dichlorobenzene or 1, 4-dichlorobenzene. In contrast to the isomers 1, 2-dichlorobenzene (especially hepatotoxicity) and 1, 4-dichlorobenzene (especially renal toxicity), 1, 3-dichlorobenzene showed only minimal effects on the kidney.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
