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Administrative data

Link to relevant study record(s)

Description of key information

In an in vivo study, conducted on 4 rodent species using radio labelled [14C] 2-aminobiphenyl (2-ABP), using intra-peritoneal route of administration, the results of the metabolism and excretion indicate that after metabolism, 40 to 50 % chemical is excreted out of the living system via renal elimination within 5 days.  This suggests that the chemical biphenyl-2-ylamine (Synonym - 2-aminobiphenyl) shall have low bioaccumulation potential. The study also concludes that the chemical is relatively non-toxic given its failure to be converted to N-oxidation products.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The chemical biphenyl-2-ylamine (Synonym -2-aminobiphenyl) CAS No 90-41-5 was administered intra-peritoneally to 4 rodent species namely albino mice, Wistar albino rats, Syrian golden hamsters, and albino Dunkin-Hartley guinea pigs. The results of the metabolism and excretion indicate that after metabolism, 40 to 50 % chemical is excreted out of the living system via renal elimination within 5 days. This suggests that the chemical biphenyl-2-ylamine (Synonym -2-aminobiphenyl) shall have low bioaccumulation potential. The study also concludes that the chemical is relatively non-toxic given its failure to be converted to N-oxidation products.