Registration Dossier
Registration Dossier
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EC number: 202-085-1 | CAS number: 91-63-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Pevny and Hutzler,Dermatosen in Beruf und Umwelt 36(3):91-98,1988, 2-methylquinoline induced dermal sensitization in human patch testing. However, reactions to 2-methylquinoline and to certain other compounds were "considered to be group allergies since contact is hardly possible with these substances [in isolation] in everyday life". Moreover, 2-methylquinoline is a transported isolated intermediate, it is used under strictly controlled condition so the exposure to the substance is minimized and there is no reason of concern regarding its skins sensitisation.
Migrated from Short description of key information:
In human patch testing 2-methylquinoline induced dermal sensitisation but the effect is due to the combination with other substances.
Justification for selection of skin sensitisation endpoint:
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The positive results regarding skin sensitisation of 2 -methylquinoline are due to combination with other substances.
2-methylquinoline is a transported isolated intermediate, it is used under strictly controlled condition so the exposure to the substance is minimized and there is no reason of concern regarding its skins sensitisation.
No classification for skin sensatisation is proposed for 2 -methylquinoline according to according to CLP Regulation (EC n.1272/2008).
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