Registration Dossier
Registration Dossier
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EC number: 202-085-1 | CAS number: 91-63-4
Endpoint summary
Administrative data
Description of key information
2-methylquinoline is of certain concern regarding acute toxicity.
The oral LD50 rats is 1230 mg/kg/bw.
The dermal LD50 rabbit is 1870 µL/kg equivalent to 1980 mg/kg.
No data are available regarding acute toxicity of 2-methylquinoline for inhalation route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 230 mg/kg bw
- Quality of whole database:
- Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 980 mg/kg bw
- Quality of whole database:
- Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002
Additional information
2-methylquinoline is of certain concern regarding acute toxicity. The oral LD50 rats is 1230 mg/kg/bw. The dermal LD50 rabbit is 1870 µL/kg equivalent to 1980 mg/kg. No data are available regarding acute toxicity for inhalation route.
Oral exposure:
As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951 when 2-methylquinoline was administered orally to rats, the LD50 was 1230 mg/kg.
Inhalation exposure:
No data available.
Dermal exposure:
As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to AMA Archives of Industrial Hygiene and Occupational Medicine.Vol. 4, Pg. 119, 1951 when 2-methylquinoline was applied to the skin of the rabbit, the LD50 was 1870 µL/kg equivalent to 1980 mg/kg.
Justification for classification or non-classification
Based on LD50 oral rat= 1230 mg/kg/bw and LD50 dermal rabbit= 1980 mg/kg/bw 2-methylquinoline is classified H302 (acute oral toxicity cat.4) and H312 (acute dermal toxicity cat.4) according to CLP Regulation (EC n.1272/2008).
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