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EC number: 203-266-8 | CAS number: 105-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database and secondary source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance 1,4-Bis(ethenyl)benzene.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (IUPAC Name): 1,4-Bis(ethenyl)benzene- Molecular formula: C10H10- Molecular weight: 130.189 g/mol- Smiles notation: C(c1ccc(cc1)C=C)=C- InChI: 1S/C10H10/c1-3-9-5-7-10(4-2)8-6-9/h3-8H,1-2H2 - Substance type: Organic- Physical state: Solid
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Concentration of sludge: 30 mg/l
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- other: BOD and GC
- Details on study design:
- Improved type for a volatile substance
- Parameter:
- other: BOD
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- other: Other details not known
- Parameter:
- other: GC
- Value:
- 3
- Sampling time:
- 28 d
- Remarks on result:
- other: Other details not known
- Details on results:
- Test substance undergoes 0 and 3% degradation by BOD and GC parameter in 28 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The percentage degradation of test substance 1,4-Bis(ethenyl)benzene was determined to be 0 and 3% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, 1,4-Bis(ethenyl)benzene is considered to be not readily biodegradable in water.
- Executive summary:
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance1,4-Bis(ethenyl)benzene (CAS no. 105-06-6). Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance 1,4-Bis(ethenyl)benzene was determined to be 0 and 3% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, 1,4-Bis(ethenyl)benzene is considered to be not readily biodegradable in nature.
Reference
Description of key information
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance1,4-Bis(ethenyl)benzene (CAS no. 105-06-6) (from authoritative database (J-CHECK, 2018) and secondary source). Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance 1,4-Bis(ethenyl)benzene was determined to be 0 and 3% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, 1,4-Bis(ethenyl)benzene is considered to be not readily biodegradable in nature.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Experimental study and predicted data for the target compound 1,4-Bis(ethenyl)benzene(CAS No. 105-06-6) and various supporting studies for its structurally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study from authoritative database (J-CHECK, 2018) and secondary source, biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance1,4-Bis(ethenyl)benzene (CAS no. 105-06-6). Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance 1,4-Bis(ethenyl)benzene was determined to be 0 and 3% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, 1,4-Bis(ethenyl)benzene is considered to be not readily biodegradable in nature.
In a prediction using the Estimation Programs Interface Suite (2018), the biodegradation potential of the test compound 1,4-Bis(ethenyl)benzene (CAS no. 105 -06 -6) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1,4-Bis(ethenyl)benzene is expected to be not readily biodegradable.
For the test chemical from authoritative databases (2018),biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 0, 1 and 4% by BOD, TOC removal and HPLC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
In a supporting study from authoritative databases (J-CHECK, 2018 and EnviChem, 2014) for the test item,biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I). Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 2 and 0% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical1,4-Bis(ethenyl)benzene(from authoritative database, secondary source and modelling database, 2017), it can be concluded that the test substance 11,4-Bis(ethenyl)benzenecan be expected to be not readily biodegradable in nature.
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